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Advanced filters: Author: Azman Embarc-Buh Clear advanced filters

Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome

This study introduces a chemical method, BACS, that generates Ψ-to-C mutation signatures, allowing for sequencing and quantification of Ψ at single-base resolution.

Haiqi Xu
Linzhen Kong
Chun-Xiao Song
ResearchOpen Access30 Sept 2024
Nature Methods

Volume: 21, P: 2024-2033
Structural basis for Gemin5 decamer-mediated mRNA binding

Structural biology, complemented by biochemistry experiments and RNA-binding assays show that the Gemin5 C-terminal region adopts a decamer architecture. Gemin5 decamerization is essential for its role in regulating mRNA translation.

Qiong Guo
Shidong Zhao
Chao Xu
ResearchOpen Access02 Sept 2022
Nature Communications

Volume: 13, P: 1-10
Oligomerization regulates the interaction of Gemin5 with members of the SMN complex and the translation machinery

Rosario Francisco-Velilla
Salvador Abellan
Encarnacion Martinez-Salas
ResearchOpen Access28 Jun 2024
Cell Death Discovery

Volume: 10, P: 1-14