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Expedited access to polyunsaturated fatty acids and biofunctional analogues by full solid-phase synthesis

Polyunsaturated fatty acids (PUFAs) are attracting considerable interest because of their diverse structures and properties. Now a method to access a wide array of PUFAs by full solid-phase synthesis has been developed and used to discover an anti-inflammatory fatty acid.

Yutaro Saito
Mayuko Akita
Shinsuke Sando
Research25 Jun 2025
Nature Chemistry

Volume: 17, P: 1391-1400
Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

Here, the authors inversely associate Blautia wexlerae with obesity and type 2 diabetes mellitus in humans and further show that administration of B. wexlerae to mice decrease both high-fat diet–induced obesity and diabetes via modulating gut microbial metabolism.

Koji Hosomi
Mayu Saito
Jun Kunisawa
ResearchOpen Access18 Aug 2022
Nature Communications

Volume: 13, P: 1-17
Mechanical properties of cold-drawn films of ultrahigh-molecular-weight poly(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Haloferax mediterranei

We investigated the biosynthesis and properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) produced by Haloferax mediterranei from glucose. Size-exclusion chromatography revealed that PHBV produced by H. mediterranei in flask cultures had a weight-average molecular weight of 4.7 × 10⁶ g/mol, demonstrating production of ultrahigh-molecular-weight (UHMW) PHBV. The UHMW-PHBV (7 mol% 3-hydroxyvalerate, M_w = 4.4 × 10⁶ g/mol) obtained by jar fermenter cultivation was used to produce tenfold cold-drawn films with a tensile strength of 258.7 MPa. This suggests that UHMW-PHBV has a potential for practical, strong films.

Kotaro Ino
Shun Sato
Tomotake Morita
Research25 Jun 2020
Polymer Journal

Volume: 52, P: 1299-1306
Accelerated degradation of plastic products via yeast enzyme treatment

Hiroko Kitamoto
Motoo Koitabashi
Tokuma Fukuoka
ResearchOpen Access10 Feb 2023
Scientific Reports

Volume: 13, P: 1-11
Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques

Takahiro Nagatake
Shigenobu Kishino
Jun Kunisawa
ResearchOpen Access10 Jan 2022
Mucosal Immunology

Volume: 15, P: 289-300
12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice

Takahiro Nagatake
Yuki Shibata
Jun Kunisawa
ResearchOpen Access17 May 2021
Scientific Reports

Volume: 11, P: 1-11

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Expedited access to polyunsaturated fatty acids and biofunctional analogues by full solid-phase synthesis

Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

Mechanical properties of cold-drawn films of ultrahigh-molecular-weight poly(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Haloferax mediterranei

Accelerated degradation of plastic products via yeast enzyme treatment

Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques

12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice

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Expedited access to polyunsaturated fatty acids and biofunctional analogues by full solid-phase synthesis

Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota

Mechanical properties of cold-drawn films of ultrahigh-molecular-weight poly(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Haloferax mediterranei

Accelerated degradation of plastic products via yeast enzyme treatment

Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques

12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice

Search

Quick links