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Showing 1–5 of 5 results
Advanced filters: Author: Bárbara González-Terán Clear advanced filters

  • mTOR signalling pathway is a critical regulator of cardiac hypertrophy. Here the authors show that two kinases, p38γ and p38δ, control heart growth by promoting mTOR activity via phosphorylation and consequent proteasome degradation of mTOR inhibitor DEPTOR, extending our knowledge of cardiac hypertrophy regulation.

    • Bárbara González-Terán
    • Juan Antonio López
    • Guadalupe Sabio
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16

  • The stress-activated kinase p38γ has a role in regulating entry into the cell cycle; in the liver, it can induce cellular proliferation during regeneration and promote the development of hepatocellular carcinoma.

    • Antonia Tomás-Loba
    • Elisa Manieri
    • Guadalupe Sabio
    Research
    Nature
    Volume: 568, P: 557-560

  • Romero-Becerra et al. report that stress kinases p38γ and p38δ are activated in ventricles of old mice and in arrhythmogenic conditions, and they demonstrate that p38γ/δ -driven phosphorylation of RyR2 and SAP97 is a trigger for ventricular fibrillation.

    • Rafael Romero-Becerra
    • Francisco M. Cruz
    • Guadalupe Sabio
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 1204-1220

  • p53 regulates lipid metabolism and fatty acid oxidation, and its inactivation promotes diet-induced liver steatosis. Here Porteiroet al. show that p53 deficiency leads to compensatory p63 upregulation, which, in turn, triggers endoplasmic reticulum stress through IKKβ activation, fatty acid synthesis and lipid accumulation.

    • Begoña Porteiro
    • Marcos F. Fondevila
    • Ruben Nogueiras
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19