The adult kidney vasculature comprises diverse populations of endothelial cells that support specific functions according to their microenvironment. This Review summarizes our current understanding of the phenotypic, molecular and metabolic heterogeneity of renal endothelial cells in relation to their microenvironment and the potential application of targeting renal endothelial cell metabolism as a therapeutic strategy for kidney diseases or kidney regeneration.
- Sébastien J. Dumas
- Elda Meta
- Peter Carmeliet
