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Molecular glue degraders have consistently been discovered retrospectively, despite their increasing importance. Herein, a high-throughput approach is described that modifies existing ligands into molecular glue degraders.

Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.

This study presents a scalable and sustainable electro-membrane crystallization-assisted general recycling technology that efficiently recovers high-purity lithium, manganese, nickel, and cobalt from spent lithium-ion batteries.

Microscopic imaging and biochemical studies show that sinuses in mouse and human form a highly dynamic surface that regulates fluid movement and immune cell surveillance via RAMP1-dependent regulation of smooth muscle contraction and RAMP2-dependent regulation of the sinus endothelial barrier.

The meningeal compartment communicates with the brain to modulate homeostatic functions. Here, the authors demonstrate that natural killer (NK) cells and innate lymphoid cells (ILC) 1 shape synaptic neuronal transmission and affect mouse behavior.

Targeted ablation of prostaglandin E₂ (PGE₂) signalling in CAR T cells enhances their activity in PGE₂-rich solid tumours, with demonstrations of efficacy in vitro, in mouse xenografts and in patient-derived organotypic tumour spheroids.

In the nucleus accumbens, acetylcholine boosts dopamine release to promote effortful behaviour.

A genetic study of natural variation in potato tuberization onset, an important phenotype for breeding potatoes adapted to different global day lengths, has revealed a role for StCDF1, a member of the DOF family of transcription factors.

Glucose deprivation triggers the secretion of the cytokine LIF, which promotes angiogenesis and immune suppression in lung cancer models.

Kathiriya et al. identify a cardiac progenitor lineage with expression of Tbx5 and anterior heart field-specific expression of Mef2c that bisects the intraventricular septum during development and show that alterations in this lineage lead to congenital heart defects in mice.

Here, the authors present mtDNA and chronological data for sediments from excavations in the South Chamber of Denisova Cave, from which they construct a timeline of hominin and faunal occupation that fills stratigraphic gaps in other parts of the cave.

The authors developed self-incompatible diploid potatoes via haploid breeding. The resulting F₁ hybrids prevent fruit set, redirect photoassimilates to tubers, increase the harvest index and enable scalable hybrid seed production.

The authors show shifts in predatory spider web mesh size under experimental warming in an alpine meadow. Web mesh size decreased for a large spider species, but increased for a small species, with changes linked to altered prey size spectra following soil moisture and plant community shifts.

Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

Cell-to-cell variability limits efficient microbial production. Here, the authors track single cells to reveal enzyme noise as the main source of bioproduction variation, and by coupling growth to pathway performance, they selectively enrich high producers and substantially boost overall titres.

Here they show that the adhesion GPCR Gpr126/Adgrg6 regulates trabeculation during heart development. Its N-terminal fragment is required for maintaining cell adhesion and compact wall integrity while its C-terminal fragment is essential to provide trabecular identity.

Rancid odors trigger retching and aversion. Here, authors show a nose-to-brain axis whereby such odors activate olfactory-piriform circuits that diverge to mediodorsal thalamic nucleus and nucleus accumbens to mediate retching-like behavior and aversion.

The method for separating Cl₂ based on the Bernoulli principle enables efficient electrochemical chlorine evolution under universal pH conditions in a three-phase system. This enables assembly of a membrane-free system that can resist the influence of pH changes in the electrolyte.

De novo domestication was performed on the brassica Thlaspi arvense (pennycress) by identifying and stacking CRISPR-induced mutations to create a new intermediate oilseed crop that can be grown in the off-season, with seed compositions similar to canola (low erucic acid and reduced glucosinolate).

Spinal cord injury can induce synaptic reorganization and remodeling in the brain. Here the authors study how severed distal axons signal back to the cell body to induce hyperexcitability, loss of inhibition and enhanced presynaptic release through netrin-1.

The mechanisms underlying oligodendrocyte precursor cells (OPCs) and neuron interactions remain unclear. Here, the authors show that chromatin remodeler BAF155 regulates OPC differentiation and myelination by coordinating synaptic genes for OPC neuron communication, contributing to autism-like behavioral deficits in mice

The deactivation of CO₂ reduction electrocatalyst in microbial media remains a key barrier for hybrid bio-electrochemical systems. Here, the authors present a bioadaptive nickel single atom catalyst that resists organic poisoning to enable high-rate CO-mediated isopropanol production from CO₂.

The release of carbon dioxide during oxidative weathering of sedimentary rocks acts as a positive feedback to warming, according to 2.5 years of CO₂ flux measurements from the Draix-Bléone Critical Zone Observatory, France.

This protocol describes procedures for speed-breeding approaches using growth cabinets and LED-supplemented glasshouses. The approaches can be used to accelerate crop research and are compatible with a wide variety of crops.

The degree to which the diurnal light/dark cycle influences Mg-heterogeneity in foraminifera with complex shell morphologies remains unknown. Here, using highly spatially resolved analytical techniques, the authors investigate Mg-banding and calcification in isotope-labelledNeogloboquadrina dutertreispecimens.

This study reports a microfluidic device based on electrochemiluminescence detection that can be potentially operated without electricity, since it functions exploiting the concept of streaming potential-driven bipolar electrochemistry.

The human CYFIP1 gene is linked to brain connectivity defects in neurodevelopmental disorders (NDDs). Here authors showed that reduced calcium uptake underlies CYFIP1-related axonal defects, potentially contributing to NDDs.

Parallelized single-molecule fluorescence and single-molecule FRET experiments enable quantitative biophysics investigations of molecular function from multiple samples in a single experiment.

Heat flows through thin, crack-like geo-compartments are shown to purify previously mixed compounds and enhance their reactivity, providing a selective mechanism for separating molecules relevant to the chemical origins of life.

The key regulators driving intrinsic immune responses and neuropathic pain remain elusive. Here, the authors elucidate that ZFP612-mediated epigenetic disinhibition of Il1rl1 within the 3D genome in dorsal root ganglion neurons causes neuropathic pain.

This study finds stem-like endothelial cells in the optic nerve that supply and repair retinal blood vessels after injury, revealing a hierarchical repair system that may enable new treatments for blinding vascular eye diseases.

Ribonucleoprotein (RNP) granules are responsible for mRNA transport and local translation required for neuronal and oocyte maturation. Here the authors show that loss of the Drosophila Ub ligase Hecw enlarges RNP granules, leads to a liquid to gel-like transition, and results in defective oogenesis and neuronal loss.

A recently developed class of magneto-sensitive fluorescent proteins are engineered to alter the properties of their response to magnetic fields and radio frequencies, enabling multimodal sensing of biological systems.

Vortices in an electron fluid are directly observed in a para-hydrodynamic regime in which the spatial diffusion of electron momenta is enabled by small-angle scattering rather than electron–electron scattering.

It is unclear how cell compartmentalization emerged in prebiotic conditions. Now it is shown that a temperature gradient in a confined space can bring the core components of a cell together.

One of three back-to-back papers to show that dosage of BACH2 can modulate T cell differentiation and function and how we might apply this to enhance CAR T cell therapies for cancer.