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Showing 1–50 of 222 results

Advanced filters: Author: B Hannon Clear advanced filters

The p21 cyclin–dependent kinase inhibitor suppresses tumorigenicity in vivo

Zhi-Yong Yang
Neil D. Perkins
Gary J. Nabel
Research01 Oct 1995
Nature Medicine

Volume: 1, P: 1052-1056
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus

Serum urate concentration can be studied in large datasets to find genetic and epigenetic loci that may be related to cardiometabolic traits. Here the authors identify and replicate 100 urate-associated CpGs, which provide insights into urate GWAS loci and shared CpGs of urate and cardiometabolic traits.

Adrienne Tin
Pascal Schlosser
Anna Köttgen
ResearchOpen Access09 Dec 2021
Nature Communications

Volume: 12, P: 1-18
Natural RNA circles function as efficient microRNA sponges

A natural circular RNA termed ciRS-7 is shown to function as a negative regulator of microRNA; ciRS-7 acts as an efficient sponge for the microRNA miR-7, and is resistant to the usual microRNA-mediated degradation pathway of exonucleolytic RNA decay.

Thomas B. Hansen
Trine I. Jensen
Jørgen Kjems
Research27 Feb 2013
Nature

Volume: 495, P: 384-388
The value of the world's ecosystem services and natural capital

Robert Costanza
Ralph d'Arge
Marjan van den Belt
Research15 May 1997
Nature

Volume: 387, P: 253-260
3D atomic structure from a single X-ray free electron laser pulse

X-ray Free Electron Lasers allow fast structure determination. Here, the authors push the temporal limit of atomic level structure determination to 25 fs, the length of a single pulse, paving the way to the study of fast, non-repeatable processes.

Gábor Bortel
Miklós Tegze
Gyula Faigel
ResearchOpen Access01 Feb 2024
Nature Communications

Volume: 15, P: 1-7
Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases

Alcohol use disorder and drinks per week both have been studied genetically and have different correlations with psychiatric diseases. Here the authors integrate multi-omics data to identify unique and shared variants, genes and pathways for alcohol use disorder and drinks per week.

Manav Kapoor
Michael J. Chao
Alison Goate
ResearchOpen Access20 Aug 2021
Nature Communications

Volume: 12, P: 1-12
Reduction of transcription by homologue asynapsis in Drosophila imaginal discs

Andrew S. Goldsborough
Thomas B. Kornberg
Research27 Jun 1996
Nature

Volume: 381, P: 807-810
A cognitive neural circuit biotype of depression showing functional and behavioral improvement after transcranial magnetic stimulation in the B-SMART-fMRI trial

The authors investigate functional connectivity before and after transcranial magnetic stimulation in veterans with treatment-resistant depression stratified by cognitive biotype, demonstrating associated brain connectivity-mediated improvement in cognitive behavioral task performance.

Leonardo Tozzi
Claire Bertrand
Leanne Maree Williams
ResearchOpen Access05 Jul 2024
Nature Mental Health

Volume: 2, P: 987-998
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

Carlos Caldas
Stephan A. Hahn
Scott E. Kern
Research01 Sept 1994
Nature Genetics

Volume: 8, P: 27-32
Cross-tissue correlations of genome-wide DNA methylation in Japanese live human brain and blood, saliva, and buccal epithelial tissues

Shota Nishitani
Makoto Isozaki
Akemi Tomoda
ResearchOpen Access27 Feb 2023
Translational Psychiatry

Volume: 13, P: 1-10
Identification of SENP7 and UTF1/VENTX as new loci influencing clustered protocadherin methylation across blood and brain using a genome-wide association study

Yunfeng Liu
Maja Vukic
Bastiaan T. Heijmans
Research02 Oct 2025
Molecular Psychiatry

P: 1-13
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology.

Wouter van Rheenen
Rick A. A. van der Spek
Jan H. Veldink
ResearchOpen Access06 Dec 2021
Nature Genetics

Volume: 53, P: 1636-1648
Efficient and bright organic light-emitting diodes on single-layer graphene electrodes

Indium tin oxide, the predominant material used as transparent electrodes in organic LEDs, is expensive and brittle. Ning Li and colleagues form transparent electrodes using single-layer graphene to construct organic LEDs with unprecedented performance that are suitable for both displays and lighting.

Ning Li
Satoshi Oida
Tze-Chiang Chen
Research12 Aug 2013
Nature Communications

Volume: 4, P: 1-7
Physically unclonable cryptographic primitives using self-assembled carbon nanotubes

Random two-dimensional arrays of carbon nanotubes, which are self-assembled via ion-exchange chemistry, can be used to create cryptographic keys by determining the connection yield and switching type of the nanotube devices.

Zhaoying Hu
Jose Miguel M. Lobez Comeras
Shu-Jen Han
Research22 Feb 2016
Nature Nanotechnology

Volume: 11, P: 559-565
Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis—findings from the EU-GEI study

Luis Alameda
Zhonghua Liu
Chloe C. Y. Wong
Research17 Apr 2023
Molecular Psychiatry

Volume: 28, P: 2095-2106
Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor

Myeloid cells are implicated in the innate immune and inflammatory response during infection with Chlamydia trachomatis. Here the authors show the evasion of the neutrophil response to infection and concomitant induction of sterile immunity via the purinergic P2X7 receptor.

Chunfu Yang
Lei Lei
Harlan D. Caldwell
ResearchOpen Access15 Sept 2021
Nature Communications

Volume: 12, P: 1-16
Genome-wide mapping of genetic determinants influencing DNA methylation and gene expression in human hippocampus

Most SNPs are located in non-coding genomic regions and their function remains elusive. Here, the authors perform a genome-wide scan of expression and DNA methylation quantitative trait loci in human hippocampal tissue to provide a resource for the functional interpretation of SNPs in brain disorders.

Herbert Schulz
Ann-Kathrin Ruppert
Sven Cichon
ResearchOpen Access15 Nov 2017
Nature Communications

Volume: 8, P: 1-11
Loss of cyclin-dependent kinase inhibitor genes and chromosome 9 karyotypic abnormalities in human bladder cancer cell lines

J Southgate
J Proffitt
P Selby
Research01 Nov 1995
British Journal of Cancer

Volume: 72, P: 1214-1218
SARS-CoV-2 infection and persistence in the human body and brain at autopsy

A study reports the distribution, replication and persistence of SARS-CoV-2 throughout the human body including in the brain at autopsy from acute infection to more than seven months following symptom onset.

Sydney R. Stein
Sabrina C. Ramelli
Daniel S. Chertow
Research14 Dec 2022
Nature

Volume: 612, P: 758-763
Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties

Artificial self-assembling systems such as anion receptors or ‘binders’ are largely unexplored for therapeutic applications. Here, the authors report self-assembling trimetallic cryptands containing copper, zinc or manganese that encapsulate a range of anions, are highly toxic to human cancer cell lines and show metal-dependent selectivity towards cancer vs. healthy cells linked to the selective inhibition of multiple kinases.

Simon J. Allison
Jaroslaw Bryk
Craig R. Rice
ResearchOpen Access23 Jun 2021
Nature Communications

Volume: 12, P: 1-15
Tirzepatide on ingestive behavior in adults with overweight or obesity: a randomized 6-week phase 1 trial

In a 6-week randomized phase 1 trial, tirzepatide led to reduced caloric intake during a meal test at week 3 compared with placebo and liraglutide in people with overweight or obesity.

Corby K. Martin
Owen T. Carmichael
Tamer Coskun
ResearchOpen Access24 Jun 2025
Nature Medicine

Volume: 31, P: 3141-3150
Fatty acylated toxin structure

W. Dale Branton
Marla S. Rudnick
Larry D. Bowers
Research07 Oct 1993
Nature

Volume: 365, P: 496-497
Meta-analyses identify DNA methylation associated with kidney function and damage

Many genetic loci have been identified to be associated with kidney disease, but the molecular mechanisms are not well understood. Here, the authors perform epigenome-wide association studies on kidney function measures to identify epigenetic marks and pathways involved in kidney function.

Pascal Schlosser
Adrienne Tin
Alexander Teumer
ResearchOpen Access09 Dec 2021
Nature Communications

Volume: 12, P: 1-16
Flow of Red Blood Cells stopped by Ultrasound

MARY DYSON
B. WOODWARD
J. B. POND
Research20 Aug 1971
Nature

Volume: 232, P: 572-573
Crystal Structure of Dicinnamyl Disulphide

G. W. SMITH
P. E. WHYMAN
Research06 Jun 1964
Nature

Volume: 202, P: 999-1000
Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease

Parkinson’s disease (PD) is a common neurodegenerative disorder with a complex etiology involving genetics and the environment. Here, Vallerga et al. identify two CpG probes associated with PD in a blood cell type-corrected epigenome-wide meta-analysis, implicating the SLC7A11 gene as a plausible biological target.

Costanza L. Vallerga
Futao Zhang
Jacob Gratten
ResearchOpen Access06 Mar 2020
Nature Communications

Volume: 11, P: 1-10
Fine Structure of the Dinoflagellate Transverse Flagellum

B. LEADBEATER
J. D. DODGE
Research28 Jan 1967
Nature

Volume: 213, P: 421-422
Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

WL Blalock
C Weinstein-Oppenheimer
JA McCubrey
Reviews09 Aug 1999
Leukemia

Volume: 13, P: 1109-1166
Juvenile Sterility in Male Ticks of Ornithodoros tholozani

B. FELDMAN-MUHSAM
YAEL HAVIVI
Research28 Jan 1967
Nature

Volume: 213, P: 422-423
Differences in white blood cell proportions between schizophrenia cases and controls are influenced by medication and variations in time of day

Jonelle D. Villar
Anne-Kristin Stavrum
Stephanie Le Hellard
ResearchOpen Access17 Jun 2023
Translational Psychiatry

Volume: 13, P: 1-7
Unmasking of fetal determinants on adult bone marrow cells

C. H. Granatek
B. M. Scheinberg
P. M. Corry
Research11 Oct 1979
Nature

Volume: 281, P: 484-485
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

Giulia B. Celli
Titia de Lange
Research19 Jun 2005
Nature Cell Biology

Volume: 7, P: 712-718
Experimental phase determination of the structure factor from Kossel line profile

G. Faigel
G. Bortel
M. Tegze
ResearchOpen Access11 Mar 2016
Scientific Reports

Volume: 6, P: 1-8
DNA methylation and general psychopathology in childhood: an epigenome-wide meta-analysis from the PACE consortium

Jolien Rijlaarsdam
Marta Cosin-Tomas
Charlotte A. M. Cecil
Research16 Nov 2022
Molecular Psychiatry

Volume: 28, P: 1128-1136
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Shyam K. Sharan
Masami Morimatsu
Allan Bradley
Research24 Apr 1997
Nature

Volume: 386, P: 804-810
p53 modulation of TFIIH–associated nucleotide excision repair activity

X.W. Wang
H. Yeh
C.C. Harris
Research01 Jun 1995
Nature Genetics

Volume: 10, P: 188-195
Asparagine bioavailability governs metastasis in a model of breast cancer

In a mouse model of breast cancer, asparagine bioavailability strongly influences metastasis and this is correlated with the production of proteins that regulate the epithelial-to-mesenchymal transition, which provides at least one potential mechanism for how a single amino acid could regulate metastatic progression.

Simon R. V. Knott
Elvin Wagenblast
Gregory J. Hannon
Research07 Feb 2018
Nature

Volume: 554, P: 378-381
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

Over evolutionary time genes can undergo duplication, and may accumulate mutations that render them non-functional pseudogenes, which are thought to be uninteresting. This study (and that of the group of Hannon) shows that pseudogenes can in fact influence gene expression.

Toshiaki Watanabe
Yasushi Totoki
Hiroyuki Sasaki
Research10 Apr 2008
Nature

Volume: 453, P: 539-543
Autism-associated SNPs in the clock genes npas2, per1 and the homeobox gene en2 alter DNA sequences that show characteristics of microRNA genes.

Brad Nicholas
Michael Owen
Thomas Caspari
ResearchOpen Access07 Oct 2008
Nature Precedings

P: 1
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

Adrian Merlo
James G. Herman
David Sidransky
Research01 Jul 1995
Nature Medicine

Volume: 1, P: 686-692
Principle of direct van der Waals epitaxy of single-crystalline films on epitaxial graphene

Large-scale growth of single crystals on graphene can be useful for the development of 3D/2D or 2D/2D heterostructures. Here, through careful control of growth kinetics, the authors perform multiple cycles of direct growth/transfer of high-quality single-crystal GaN, using a single graphene/SiC substrate.

Jeehwan Kim
Can Bayram
Devendra K. Sadana
Research11 Sept 2014
Nature Communications

Volume: 5, P: 1-7
Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals

Patricia R. Braun
Shizhong Han
Gen Shinozaki
ResearchOpen Access31 Jan 2019
Translational Psychiatry

Volume: 9, P: 1-10
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent risk loci. Comparisons with other psychiatric disorders and candidate gene analyses provide new insights into major depressive disorder.

Naomi R. Wray
Stephan Ripke
Patrick F. Sullivan
Research26 Apr 2018
Nature Genetics

Volume: 50, P: 668-681
Spontaneous assembly of a hinged coordination network

Geoffrey B. Gardner
D. Venkataraman
Stephen Lee
Research27 Apr 1995
Nature

Volume: 374, P: 792-795
Molecular analysis of cyclin-dependent kinase inhibitors in human leukemias

S Hayette
X Thomas
R Rimokh
Research01 Oct 1997
Leukemia

Volume: 11, P: 1696-1699
Neuropeptide Y distribution in human brain

T. E. Adrian
J. M. Allen
J. M. Polak
Research08 Dec 1983
Nature

Volume: 306, P: 584-586
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

The heterogeneity of breast cancer has a major role in drug response and resistance. In this study, the authors use patient-derived tumour xenografts as a platform for drug testing and correlation with single-cell proteomic phenotypes characterized by mass cytometry.

Dimitra Georgopoulou
Maurizio Callari
Carlos Caldas
ResearchOpen Access31 Mar 2021
Nature Communications

Volume: 12, P: 1-18
Gene expression signatures of individual ductal carcinoma in situ lesions identify processes and biomarkers associated with progression towards invasive ductal carcinoma

Progression from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) remains poorly understood. Here, the authors analyse over 2700 micro-dissected samples using transcriptomics to identify genes that characterise different stages of DCIS to IDC progression, and identify IDC-associated markers within early-stage lesions.

Clare A. Rebbeck
Jian Xian
Gregory J. Hannon
ResearchOpen Access13 Jun 2022
Nature Communications

Volume: 13, P: 1-14
Trace gas emissions on geological faults as indicators of underground nuclear testing

C. R. Carrigan
R. A. Heinle
J. J. Zucca
Research08 Aug 1996
Nature

Volume: 382, P: 528-531
Genes involved in cell cycle G₁ checkpoint control are frequently mutated in human melanoma metastases

A Platz
P Sevigny
U Ringborg
Research01 Sept 1996
British Journal of Cancer

Volume: 74, P: 936-941

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