Nature Search

Native iron reduces CO₂ to intermediates and end-products of the acetyl-CoA pathway

The acetyl-CoA pathway is the most ancient CO₂ fixation pathway in nature. Here, the authors show that metals selectively reduce CO₂ to the intermediates and end-products of the acetyl-CoA pathway, which is consistent with a prebiotic origin of this pathway.

Sreejith J. Varma
Kamila B. Muchowska
Joseph Moran
Research23 Apr 2018
Nature Ecology & Evolution

Volume: 2, P: 1019-1024
Neutralizing and binding antibodies are a correlate of risk of COVID-19 in the CoVPN 3008 study in people with HIV

Using data from the CoVPN 3008 study, the authors show that the neutralizing antibody correlate of risk holds in people living with HIV. However, the nAb correlate was weaker and shorter-lived in a vaccine-immunity versus hybrid-immunity population.

Nonhlanhla N. Mkhize
Bo Zhang
Peter B. Gilbert
ResearchOpen Access06 Oct 2025
Nature Communications

Volume: 16, P: 1-19
Joseph Priestley

J. B. C.
Books & Arts16 Aug 1906
Nature

Volume: 74, P: 378-379
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

Here the authors perform a trans expression quantitative trait locus meta-analysis study of over 3,700 people and link a USP18 variant to expression of 50 inflammation genes and lupus risk, highlighting how genetic regulation of immune responses drives autoimmune disease and informs new therapies.

Krista Freimann
Anneke Brümmer
Kaur Alasoo
ResearchOpen Access02 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Nature of Extensive Cosmic Ray Showers

L. JÁNOSSY
A. C. B. LOVELL
Research15 Oct 1938
Nature

Volume: 142, P: 716-717
Natural proteome diversity links aneuploidy tolerance to protein turnover

Proteomic data from natural isolates of Saccharomyces cerevisiae provide insight into how these cells tolerate aneuploidy (an imbalance in the number of chromosomes), and reveal differences between lab-engineered aneuploids and diverse natural yeasts.

Julia Muenzner
Pauline Trébulle
Markus Ralser
ResearchOpen Access22 May 2024
Nature

Volume: 630, P: 149-157
Polygenic and developmental profiles of autism differ by age at diagnosis

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Xinhe Zhang
Jakob Grove
Varun Warrier
ResearchOpen Access01 Oct 2025
Nature

P: 1-12
Sonelokimab, an IL-17A/IL-17F-inhibiting nanobody for active psoriatic arthritis: a randomized, placebo-controlled phase 2 trial

In the double-blind, placebo-controlled phase 2 ARGO trial, patients with active psoriatic arthritis treated with a nanobody targeting IL-17A and IL-17F showed substantially better disease response rates compared with those receiving placebo treatment.

Iain B. McInnes
Laura C. Coates
Joseph F. Merola
ResearchOpen Access06 Oct 2025
Nature Medicine

P: 1-12
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue

An optical detection and analysis platform quantifies aggregate density, distribution and size in fluorescently labelled post-mortem human brain tissue.

Rebecca Andrews
Bin Fu
Steven F. Lee
ResearchOpen Access01 Oct 2025
Nature Biomedical Engineering

P: 1-13
Sir Joseph Banks, the “Father of Australia”

W. B. HEMSLEY
Books & Arts27 Jan 1910
Nature

Volume: 82, P: 362
Sir Joseph Prestwich, D.C.L., F.R.S

H. B. W.
News02 Jul 1896
Nature

Volume: 54, P: 202-203
The Collected Mathematical Papers of James Joseph Sylvester

G. B. M.
Books & Arts14 Jan 1909
Nature

Volume: 79, P: 303-304
A basic framework to explain splice-site choice in eukaryotes

RNA splicing is an important mechanism for gene regulation. Here, the authors present a core logic that links sequence variation and splice-site choice across eukaryotes.

Craig I. Dent
Stefan Prodic
Sureshkumar Balasubramanian
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-14
Correspondence of Sir Joseph Banks

W. B. TURRILL
Books & Arts16 May 1959
Nature

Volume: 183, P: 1353
Prof. Joseph Paczoski

S. B.
Comments & Opinion18 Jul 1942
Nature

Volume: 150, P: 85-86
The Collected Mathematical Papers of James Joseph Sylvester, F.R.S.

G. B. M.
Books & Arts05 Dec 1912
Nature

Volume: 90, P: 379-380
The Collected Mathematical Papers of James Joseph Sylvester

G. B. M.
Books & Arts01 Dec 1904
Nature

Volume: 71, P: 98-99
The Collected Mathematical Papers of James Joseph Sylvester, FRS, &c

G. B. M.
Books & Arts02 Feb 1911
Nature

Volume: 85, P: 434-435
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

Genome-wide association meta-analyses of attention-deficit/hyperactivity disorder symptom measures and clinical diagnoses identify new risk loci, highlight putative effector genes and yield improved polygenic risk scores.

Camiel M. van der Laan
Hill F. Ip
Dorret I. Boomsma
Research17 Sept 2025
Nature Genetics

Volume: 57, P: 2427-2435
Dr Joseph Edward Rall

Jan Wolff
P Reed Larsen
Editorial01 Jul 2008
Nature Clinical Practice Endocrinology & Metabolism

Volume: 4, P: 359
Natural selection and sympatric divergence in the apple maggot Rhagoletis pomonella

Kenneth E. Filchak
Joseph B. Roethele
Jeffrey L. Feder
Research12 Oct 2000
Nature

Volume: 407, P: 739-742
Antibody-mediated LOX-1 inhibition in patients with residual inflammation after myocardial infarction: a randomized phase 2 trial

In a randomized trial of patients with a previous myocardial infarction and with residual inflammation, a monoclonal antibody targeting the LOX-1 receptor, thought to contribute to atherosclerotic plaque progression and inflammation, reduced soluble LOX-1 and interleukin-6 levels but did not lead to a substantial reduction in coronary plaque volume.

Michelle L. O’Donoghue
David A. Morrow
Marc S. Sabatine
Research25 Sept 2025
Nature Medicine

P: 1-7
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Distribution of Sodium and Potassium in Certain Cells and Tissues

NORMAN R. JOSEPH
MILTON B. ENGEL
HUBERT R. CATCHPOLE
Research16 Sept 1961
Nature

Volume: 191, P: 1175-1178
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer

Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity and offering new perspectives for targeting lineage plasticity.

Abbie S. Ireland
Daniel A. Xie
Trudy G. Oliver
ResearchOpen Access17 Sept 2025
Nature

P: 1-11
In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.

Nelson H. Knudsen
Giulia Escobar
Marcela V. Maus
Research24 Sept 2025
Nature

P: 1-10
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Maximilian Zenk
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Fine tuning towards the next generation of engineered T cells

A summary of CAR T-cell engineering approaches, including functional screening methods, gene editing and delivery advances, and optimization of metabolic fitness.

Tham T. Nguyen
Patrick Ho
Maik Luu
Reviews10 Oct 2025
Nature Biomedical Engineering

P: 1-22
Perioperative nivolumab or nivolumab plus ipilimumab in resectable diffuse pleural mesothelioma: a phase 2 trial and ctDNA analyses

As presented at the 2025 World Conference on Lung Cancer, in a multiarm phase 2 trial, perioperative immunotherapy was safe and feasible in patients with resectable diffuse pleural mesothelioma, with exploratory data suggesting that ctDNA kinetics could be informative of tumor regression and post-treatment survival.

Joshua E. Reuss
Paul K. Lee
Patrick M. Forde
ResearchOpen Access08 Sept 2025
Nature Medicine

P: 1-12
A little red dot at z = 7.3 within a large galaxy overdensity

Observed 730 Myr after the Big Bang, a little red dot is found to anchor an overdensity of eight galaxies and seems to be embedded in a massive host dark matter halo.

Jan-Torge Schindler
Joseph F. Hennawi
Riccardo Nanni
ResearchOpen Access17 Sept 2025
Nature Astronomy

P: 1-13
Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Xian-Le Bu
Wei Zhu
Kristin Fargher
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Francisco Gimeno-Valiente
Carla Castignani
Nnennaya Kanu
ResearchOpen Access10 Sept 2025
Nature Genetics

Volume: 57, P: 2226-2237
Local activity alterations in individuals with autism correlate with neurotransmitter properties and ketamine-induced brain changes

Consistent local activity reductions in autism co-localize with glutamatergic and GABAergic neurotransmission. These patterns resemble brain changes induced by ketamine, highlighting altered excitation-inhibition balance underlying autism’s neurophysiology.

Pascal Grumbach
Jan Kasper
Juergen Dukart
ResearchOpen Access09 Sept 2025
Nature Communications

Volume: 16, P: 1-11
Density-dependent network structuring within and across wild animal systems

The number of individuals in a given space influences animal interactions and network dynamics. Here the authors identify general rules underlying density dependence in animal networks and reveal some fundamental differences between spatial and social dynamics.

Gregory F. Albery
Daniel J. Becker
Shweta Bansal
Research04 Sept 2025
Nature Ecology & Evolution

P: 1-12
Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors

Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.

Shilpa Singh
Catherine E. Gleason
Matthew G. Oser
ResearchOpen Access20 Aug 2025
Nature

P: 1-12
Characterisation of between-cluster heterogeneity in malaria cluster randomised trials to inform future sample size calculations

This meta-analysis of malaria cluster trials highlights that underestimating between-cluster variation reduces statistical power. It provides refined coefficient of variation estimates to inform sample size calculations for future evaluations.

Joseph Biggs
Joseph D. Challenger
Jackie Cook
ResearchOpen Access18 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Thermodynamics-inspired high-entropy oxide synthesis

By controlling oxygen partial pressure, this study coerces Mn and Fe into divalent states, stabilizing seven new high-entropy rock salt oxides, and introduces oxygen chemical potential as a key design axis for predictive synthesis.

Saeed S. I. Almishal
Matthew Furst
Jon-Paul Maria
ResearchOpen Access02 Sept 2025
Nature Communications

Volume: 16, P: 1-9
The (CAG)_n tract of Machado–Joseph Disease gene (ATXN3): a comparison between DNA and mRNA in patients and controls

Conceição Bettencourt
Cristina Santos
Manuela Lima
Research25 Nov 2009
European Journal of Human Genetics

Volume: 18, P: 621-623
Bicentenary of the Royal Botanic Gardens, Kew

W. B. TURRILL
Research30 May 1959
Nature

Volume: 183, P: 1488-1490
Measuring the semantic priming effect across many languages

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

Erin M. Buchanan
Kelly Cuccolo
Savannah C. Lewis
Research24 Sept 2025
Nature Human Behaviour

P: 1-20
Stratified wind from a super-Eddington X-ray binary is slower than expected

The XRISM Resolve spectrum of the galactic neutron star X-ray binary, GX 13+1, reveals one of the densest winds ever seen in absorption lines.

Marc Audard
Hisamitsu Awaki
Missagh Mehdipour
ResearchOpen Access17 Sept 2025
Nature

Volume: 646, P: 57-61
In-situ thermo-mechano-chemical transformation and consolidation of Sm-Co powders via a single-step route for bulk magnet fabrication

Friction consolidation transforms brittle Sm–Co powders into dense magnets via shear-driven redox reactions and localized heating, enabling phase-selective refinement and enhanced magnetization in a single-step, low-temperature process.

Aniruddha Malakar
Andrew Martin
Bharat Gwalani
ResearchOpen Access13 Aug 2025
Nature Communications

Volume: 16, P: 1-12
Income and education show distinct links to health and happiness in daily life

Newman et al. find that higher education is consistently associated with better health indicators, while higher income correlates with greater well-being, based on a large-scale Ecological Momentary Assessment study.

David B. Newman
Amie M. Gordon
Wendy Berry Mendes
Research08 Aug 2025
Nature Human Behaviour

P: 1-14
Publisher Correction: Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes

Camiel M. van der Laan
Hill F. Ip
Dorret I. Boomsma
Amendments and Corrections29 Sept 2025
Nature Genetics

Volume: 57, P: 2604
Neural correlates of human fear conditioning and sources of variability in 2199 individuals

A large brain imaging study of over 2000 people worldwide shows that fear conditioning engages brain regions linked to emotion and attention, with differences in individuals with anxiety or depression and strong influences from task design.

Joaquim Radua
Hannah S. Savage
Miquel A. Fullana
ResearchOpen Access23 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Machado–Joseph disease in a Nigerian family: mutational origin and review of the literature

Shamsideen Abayomi Ogun
Sandra Martins
Michael F Finkel
Research30 Apr 2014
European Journal of Human Genetics

Volume: 23, P: 271-273
Distribution of Ions in Biological Systems

NORMAN R. JOSEPH
MILTON B. ENGEL
HUBERT R. CATCHPOLE
Research03 Apr 1965
Nature

Volume: 206, P: 6-10
Pleistocene terrestrial warming trend in East Asia linked to Antarctic ice sheets growth

The authors quantify terrestrial temperature evolution over the past 2 million years by fossil lipids preserved in an ancient lake in East Asia. They showed a long-term warming trend that diverges from the contemporaneous global sea surface cooling.

Huanye Wang
Weiguo Liu
Zhisheng An
ResearchOpen Access10 Sept 2025
Nature Communications

Volume: 16, P: 1-9
Analysis of segregation patterns in Machado–Joseph disease pedigrees

Conceição Bettencourt
Cristina Santos
Manuela Lima
Research01 Oct 2008
Journal of Human Genetics

Volume: 53, P: 920-923
Plasma tau biomarkers for biological staging of Alzheimer’s disease

Montoliu-Gaya, Salvadó et al. develop a blood-based model using tau biomarkers measured in a single analysis enabling biological staging of Alzheimer’s disease to support the diagnosis, prognosis and identification of patients likely to benefit from targeted therapies.

Laia Montoliu-Gaya
Gemma Salvadó
Oskar Hansson
ResearchOpen Access22 Aug 2025
Nature Aging

P: 1-12

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