Several genetic associations have been identified in patients with spondyloarthropathies, particularly ankylosing spondylitis (AS). The most recent associations uncovered which involve genes in the IL-17/IL-23 pathway enabled a better understanding of the aetiology of spondyloarthropathies, and informed the use of previously existing drugs to treat patients with these diseases—an example of how translation of hypothesis-free medical research can yield new therapeutic strategies.
- Matthew A. Brown
- Tony Kenna
- B. Paul Wordsworth
