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Showing 1–50 of 65 results

Advanced filters: Author: B Ryffel Clear advanced filters

Transcription of single-copy vitellogenin gene of Xenopus involves expression of middle repetitive DNA

Gerhart U. Ryffel
Daniel B. Muellener
Rudolf Weber
Research04 Jun 1981
Nature

Volume: 291, P: 429-431
Identification and change of collagen types in differentiating myoblasts and developing chick muscle

A. J. BAILEY
G. B. SHELLSWELL
V. C. DUANCE
Research01 Mar 1979
Nature

Volume: 278, P: 67-69
Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses

The function of type 3 innate lymphoid cells (ILC3s) in cancer is still poorly understood. Bruchard et al. demonstrate that ILC3s are critical for the recruitment of T cells to the tumor microenvironment and thereby play important roles in antitumor responses.

Mélanie Bruchard
Mannon Geindreau
François Ghiringhelli
Research31 Jan 2022
Nature Immunology

Volume: 23, P: 262-274
Molecular characterization of two myosin heavy chain genes expressed in the adult heart

V. Mahdavi
M. Periasamy
B. Nadal-Ginard
Research24 Jun 1982
Nature

Volume: 297, P: 659-664
Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Local microbiome composition influences treatment efficacy of chemotherapy in colon cancer via modulation of tolerogenic versus immunogenic ileal intestinal epithelial cell death, which in turn influences follicular helper T cell priming.

Maria Paula Roberti
Satoru Yonekura
Laurence Zitvogel
Research25 May 2020
Nature Medicine

Volume: 26, P: 919-931
Imprint switching on human chromosome 15 may involve alternative transcripts of the SNRPN gene

Bärbel Dittrich
Karin Buiting
Bernhard Horsthemke
Research01 Oct 1996
Nature Genetics

Volume: 14, P: 163-170
The intrinsic expression of NLRP3 in Th17 cells promotes their protumor activity and conversion into Tregs

Théo Accogli
Christophe Hibos
Frédérique Vegran
ResearchOpen Access07 Apr 2025
Cellular & Molecular Immunology

Volume: 22, P: 541-556
VIP occurs in intrathyroidal nerves and stimulates thyroid hormone secretion

B. Ahrén
J. Alumets
F. Sundler
Research01 Sept 1980
Nature

Volume: 287, P: 343-345
Helper T cell bias following tuberculosis chemotherapy identifies opportunities for therapeutic vaccination to prevent relapse

Yazmin B. Martinez-Martinez
Matthew B. Huante
Janice J. Endsley
ResearchOpen Access28 Oct 2023
npj Vaccines

Volume: 8, P: 1-15
Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)

Kazuya Yamagata
Hiroto Furuta
Graeme I. Bell
Research05 Dec 1996
Nature

Volume: 384, P: 458-460
Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

Lionel Apetoh
François Ghiringhelli
Laurence Zitvogel
Research19 Aug 2007
Nature Medicine

Volume: 13, P: 1050-1059
HNF4α reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma

Belén Lucas
Karen Grigo
Gerhart U Ryffel
Research13 Jun 2005
Oncogene

Volume: 24, P: 6418-6431
CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Metabolism of tryptophan by the gut microbiota is impaired by deficiencies in CARD9, leading to the worsening of colitis.

Bruno Lamas
Mathias L Richard
Harry Sokol
Research09 May 2016
Nature Medicine

Volume: 22, P: 598-605
Messenger RNA electroporation is highly efficient in mouse embryonic stem cells: successful FLPe- and Cre-mediated recombination

P Ponsaerts
JP Brown
ZN Berneman
Research05 Aug 2004
Gene Therapy

Volume: 11, P: 1606-1610
Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization

Noria Segueni
Elaine Tritto
Valerie F. Quesniaux
ResearchOpen Access17 Nov 2016
Scientific Reports

Volume: 6, P: 1-17
Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome

Natural product biosynthesis gene clusters were identified in bacterial isolates from the Arabidopsis phyllosphere, including inhibitory products with antibiotic activity, demonstrating the potential of the phyllosphere as a resource for antibiotics.

Eric J. N. Helfrich
Christine M. Vogel
Julia A. Vorholt
Research23 Jul 2018
Nature Microbiology

Volume: 3, P: 909-919
Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

Xiao-kun Zhang
Birgit Hoffmann
Magnus Pfahl
Research30 Jan 1992
Nature

Volume: 355, P: 441-446
mRNA 3’UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus

Here, Bergant et al. provide evidence that Influenza A viruses cause alternative polyadenylation of host mRNAs and abrogation of this function leads to an attenuated phenotype in mice. This may constitute a general immune evasive mechanism employed by a variety of pathogenic viruses.

Valter Bergant
Daniel Schnepf
Andreas Pichlmair
ResearchOpen Access15 Aug 2023
Nature Communications

Volume: 14, P: 1-17
The commensal skin microbiota triggers type I IFN–dependent innate repair responses in injured skin

Gilliet and colleagues demonstrate that skin wound healing occurs through the coordinated action of plasmacytoid dendritic cells, chemokines and skin microbiota.

Jeremy Di Domizio
Cyrine Belkhodja
Michel Gilliet
Research13 Jul 2020
Nature Immunology

Volume: 21, P: 1034-1045
Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses

Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human cancers. Here the authors show that inactivation of Wip1 in neutrophils promotes p53-dependent expression of co-stimulatory ligands and anti-tumor immune responses, reducing tumor growth in preclinical cancer models.

Burhan Uyanik
Anastasia R. Goloudina
Oleg N. Demidov
ResearchOpen Access15 Jun 2021
Nature Communications

Volume: 12, P: 1-15
Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

Gemcitabine and 5-fluorouracil are two commonly used chemotherapeutic agents for the treatment of cancer. François Ghiringhelli and colleagues now report that the antitumor efficacy of these agents is mitigated by myeloid derived suppressor cells (MDSCs). The authors show that these drugs can activate the NLRP3 inflammasome, leading to increased secretion of IL-1β by MDSCs and IL-17 production by CD4⁺ T cells, which can promote tumor growth.

Mélanie Bruchard
Grégoire Mignot
François Ghiringhelli
Research02 Dec 2012
Nature Medicine

Volume: 19, P: 57-64
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

Dying tumor cells release ATP, which activates the NLRP3 inflammasome in dendritic cells, enabling the secretion of interleukin-1β and the subsequent priming of tumor-specific interferon-γ-producing T lymphocytes.

François Ghiringhelli
Lionel Apetoh
Laurence Zitvogel
Research20 Sept 2009
Nature Medicine

Volume: 15, P: 1170-1178
Nitric oxide enhances Th9 cell differentiation and airway inflammation

Th9 cells are a subset of T helper cells that protect hosts against helminthic infection, but can also mediate allergic disease through overexpression of the cytokine IL-9. Here, Niedbala et al.show that nitric oxide is a potent enhancer of Th9 differentiation via the activation of p53 protein.

Wanda Niedbala
Anne-Gaelle Besnard
Foo Y. Liew
Research07 Aug 2014
Nature Communications

Volume: 5, P: 1-13
STING-dependent sensing of self-DNA drives silica-induced lung inflammation

Silica particles induce intereukin-1 (IL-1) response to contribute to lung inflammation, but the underlying mechanism is unclear. Here the authors show that silica induces cell death and release of mitochondria and genomic DNA, which are sensed by STING with or without involving cGAS, respectively, for IL-1 induction and lung inflammation.

Sulayman Benmerzoug
Stéphanie Rose
Valerie F. J. Quesniaux
ResearchOpen Access06 Dec 2018
Nature Communications

Volume: 9, P: 1-19
Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

Epithelial surfaces are the main entry point for viruses and thus are important immunological sites. Diefenbach and colleagues show that the related cytokines IL-22 and IFN-λ act together in the control of enterovirus infection.

Pedro P Hernández
Tanel Mahlakõiv
Andreas Diefenbach
Research25 May 2015
Nature Immunology

Volume: 16, P: 698-707
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens

Mutations in nucleotide-binding oligomerization domain protein 12 (NLRP12) are known to effect inflammatory processes. Here the authors show that NLRP12-mediated proteasomal degradation of NOD2 in monocytes promotes bacterial tolerance and colonisation in a model of enteric infection.

Sylvain Normand
Nadine Waldschmitt
Mathias Chamaillard
ResearchOpen Access17 Dec 2018
Nature Communications

Volume: 9, P: 1-11
Hydrogenation streamlines cyclolignan synthesis

Enantioselective hydrogenation is a stalwart reaction in synthetic chemistry. Now, hydrogenation of tetrasubstituted 1,2-dihydronaphthalene esters gives access to more than 30 cyclolignan natural products.

David B. Ryffel
David Sarlah
News & Views09 Jul 2024
Nature Synthesis

Volume: 3, P: 937-938
The receptor NLRP3 is a transcriptional regulator of T_H2 differentiation

The receptor NLRP3 is central to the formation of inflammasomes in myeloid cells. Ghiringhelli and colleagues demonstrate that NLRP3 also serves an important inflammasome-independent role in CD4⁺ T cells, in which it helps coordinate T_H2 differentiation.

Mélanie Bruchard
Cédric Rebé
François Ghiringhelli
Research22 Jun 2015
Nature Immunology

Volume: 16, P: 859-870
Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway

Reactive oxygen species (ROS) are generated by cells during viral infection. Pichlmair and colleagues demonstrate a ROS-dependent form of cell death, ‘oxeiptosis’, that resembles apoptosis but uses a pathway distinct from all previously described death pathways.

Cathleen Holze
Chloé Michaudel
Andreas Pichlmair
Research18 Dec 2017
Nature Immunology

Volume: 19, P: 130-140
Functional and morphological differences of the lung upon acute and chronic ozone exposure in mice

Chloé Michaudel
Louis Fauconnier
Bernhard Ryffel
ResearchOpen Access13 Jul 2018
Scientific Reports

Volume: 8, P: 1-10
HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1

Shiki Fujino
Norikatsu Miyoshi
Hidetoshi Eguchi
ResearchOpen Access14 May 2021
Scientific Reports

Volume: 11, P: 1-15
Central Role of CD169⁺ Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01

Sophie Detienne
Iain Welsby
Arnaud M. Didierlaurent
ResearchOpen Access20 Dec 2016
Scientific Reports

Volume: 6, P: 1-14
CCR4-dependent reduction in the number and suppressor function of CD4⁺Foxp3⁺ cells augments IFN-γ-mediated pulmonary inflammation and aggravates tuberculosis pathogenesis

Thais B. Bertolini
Annie R. Piñeros
Vânia L. D. Bonato
ResearchOpen Access21 Dec 2018
Cell Death & Disease

Volume: 10, P: 1-13
Plasma levels of tumour necrosis factor and its soluble receptors correlate with clinical features and outcome of Hodgkin's disease patients

K Warzocha
J Bienvenu
G Salles
Research01 Jun 1998
British Journal of Cancer

Volume: 77, P: 2357-2362
Construction and characterization of a recombinant adenoviral vector expressing human interleukin-12

Jian Qiao
Shu-Hsia Chen
Savio LC Woo
Research01 Nov 1999
Cancer Gene Therapy

Volume: 6, P: 373-379
TLR4/MYD88-dependent, LPS-induced synthesis of PGE₂ by macrophages or dendritic cells prevents anti-CD3-mediated CD95L upregulation in T cells

R Weinlich
K R Bortoluci
G P Amarante-Mendes
Research26 Sept 2008
Cell Death & Differentiation

Volume: 15, P: 1901-1909
NETosis exacerbates skin inflammation in obese psoriasis patients

Bruno Marcel Silva de Melo
José Carlos Alves-Filho
Bernhard Ryffel
Comments & Opinion20 May 2025
Cellular & Molecular Immunology

Volume: 22, P: 690-691
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

GNPS is an open-access community-curated analysis platform for sharing natural product mass spectrometry data that enables continuous, automatic reanalysis of deposited 'living' data sets.

Mingxun Wang
Jeremy J Carver
Nuno Bandeira
Reviews09 Aug 2016
Nature Biotechnology

Volume: 34, P: 828-837
Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses

Jiří Hrdý
Jeanne Alard
Corinne Grangette
ResearchOpen Access24 Mar 2020
Scientific Reports

Volume: 10, P: 1-11
Interleukin-22-deficiency and microbiota contribute to the exacerbation of Toxoplasma gondii-induced intestinal inflammation

A Couturier-Maillard
N Froux
B Ryffel
Research04 May 2018
Mucosal Immunology

Volume: 11, P: 1181-1190
Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells

Zhongming Tan
Qianghui Liu
Bernhard Ryffel
Research13 Feb 2017
Cellular & Molecular Immunology

Volume: 15, P: 388-398
Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells

Zhongming Tan
Qianghui Liu
Bernhard Ryffel
Research13 Feb 2017
Cellular & Molecular Immunology

Volume: 15, P: 388-398
Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines

D Hannani
C Locher
L Zitvogel
Research07 Jun 2013
Cell Death & Differentiation

Volume: 21, P: 50-58
Correction: Interleukin-22-deficiency and microbiota contribute to the exacerbation of Toxoplasma gondii-induced intestinal inflammation

A Couturier-Maillard
N Froux
B Ryffel
Amendments and Corrections30 Nov 2018
Mucosal Immunology

Volume: 12, P: 290
Defective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists

T Yamazaki
D Hannani
L Zitvogel
Research28 Jun 2013
Cell Death & Differentiation

Volume: 21, P: 69-78
STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)

Yasmine Messaoud-Nacer
Elodie Culerier
Dieudonnée Togbe
ResearchOpen Access25 Mar 2022
Cell Death & Disease

Volume: 13, P: 1-17
The osteoprotective role of USP26 in coordinating bone formation and resorption

Changwei Li
Minglong Qiu
Lianfu Deng
ResearchOpen Access29 Jan 2022
Cell Death & Differentiation

Volume: 29, P: 1123-1136
SDZ 280-446, a novel semi-synthetic cyclopeptolide: in vitro and in vivo circumvention of the P-glycoprotein-mediated tumour cell multidrug resistance

F Loor
D Boesch
G Emmer
Research01 Jan 1992
British Journal of Cancer

Volume: 65, P: 11-18
GM-CSF targeted immunomodulation affects host response to M. tuberculosis infection

Sulayman Benmerzoug
Fabio Vitarelli Marinho
Valerie F. J. Quesniaux
ResearchOpen Access05 Jun 2018
Scientific Reports

Volume: 8, P: 1-15
Myeloid cell TNFR1 signaling dependent liver injury and inflammation upon BCG infection

Leslie Chavez-Galan
Dominique Vesin
Irene Garcia
ResearchOpen Access28 Mar 2019
Scientific Reports

Volume: 9, P: 1-15

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