Nature Search

Peroxisome proliferator-activated receptors and inflammation: from basic science to clinical applications

G Chinetti
J-C Fruchart
B Staels
Research14 Nov 2003
International Journal of Obesity

Volume: 27, P: S41-S45
Circadian rhythms influence surgical outcomes

Gregory B. Lim
Research Highlights16 Nov 2017
Nature Reviews Cardiology

Volume: 15, P: 5
Fibrates and future PPARα agonists in the treatment of cardiovascular disease

Despite statin therapy, patients with diabetes still face a substantial residual cardiovascular risk. The need for additional therapies is, therefore, sorely needed. Here Staels et al. explore to what extent peroxisome proliferator-activated receptor α agonists, such as fibrates, can improve the lipid profile and associated risk markers.

Bart Staels
Michel Maes
Alberto Zambon
Reviews15 Jul 2008
Nature Clinical Practice Cardiovascular Medicine

Volume: 5, P: 542-553
Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH

GDF-15 is a cytokine regulating food intake and a potential therapeutic target for treating obesity. Here, the authors show that macrophage infiltration in adipose tissue increases GDF-15 during obesity and type 2 diabetes, and hepatocyte stress further increases its levels when developing MASH.

Laurent L’homme
Benan Pelin Sermikli
David Dombrowicz
ResearchOpen Access21 Aug 2024
Nature Communications

Volume: 15, P: 1-18
Erratum: Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes

R Dutia
M Embrey
B Laferrère
Amendments and Corrections08 Mar 2016
International Journal of Obesity

Volume: 40, P: 554
Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease

Partitioning clustering based on clinical variables applied to multiple patient cohorts identifies two subtypes of metabolic dysfunction-associated steatotic liver disease with different associations to hepatic and cardiovascular outcomes.

Violeta Raverdy
Federica Tavaglione
François Pattou
ResearchOpen Access09 Dec 2024
Nature Medicine

Volume: 30, P: 3624-3633
Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution

Non-alcoholic steatosis is characterized by lipid accumulation within hepatocytes and can progress to NASH. Haas and colleagues demonstrate that livers from people with NASH show a distinct but reversible gene profile from simple steatosis and accumulation of intrahepatic cDC and CD8 T cells.

Joel T. Haas
Luisa Vonghia
David Dombrowicz
Research14 Jun 2019
Nature Metabolism

Volume: 1, P: 604-614
Author Correction: Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution

Joel T. Haas
Luisa Vonghia
David Dombrowicz
Amendments and Corrections24 Jun 2019
Nature Metabolism

Volume: 1, P: 744
Tenascin–X deficiency is associated with Ehlers–Danlos syndrome

Grant H. Burch
Yan Gong
James Bristow
Research01 Sept 1997
Nature Genetics

Volume: 17, P: 104-108
Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

Dysregulation of PPARα dependent fatty acid oxidation promotes hepatic steatosis. Here the authors show that GPS2 inhibits PPARα activity and that ablation of GPS2 ameliorates hepatic steatosis in mice.

Ning Liang
Anastasius Damdimopoulos
Rongrong Fan
ResearchOpen Access11 Apr 2019
Nature Communications

Volume: 10, P: 1-14
PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD

Peroxisome proliferator-activated receptors (PPARs) are integrators of both inflammatory and metabolic signalling networks. In this Review, the authors provide a comprehensive overview of how PPARs contribute to the development of metabolic disorders and how pharmacologically targeting these pathways can be used to develop new therapeutics for such diseases.

Barbara Gross
Michal Pawlak
Bart Staels
Reviews16 Sept 2016
Nature Reviews Endocrinology

Volume: 13, P: 36-49
Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Here, the authors use ¹H-MRS methodology to show hepatic SFA fraction is a measure of DNL and specifically may hamper hepatic insulin sensitivity.

Kay H. M. Roumans
Lucas Lindeboom
Vera B. Schrauwen-Hinderling
ResearchOpen Access20 Apr 2020
Nature Communications

Volume: 11, P: 1-11
Leptin increases circulating glucose, insulin and glucagon via sympathetic neural activation in fasted mice

B Ahrén
PJ Havel
Research26 Jun 1999
International Journal of Obesity

Volume: 23, P: 660-665
Association of poorly controlled diabetes with low serum leptin in morbid obesity

K Clément
N Lahlou
P Froguel
Research01 Jul 1997
International Journal of Obesity

Volume: 21, P: 556-561
Insulin induces rapid changes of plasma leptin in lean but not in genetically obese (fa/fa) rats

C Pagano
P Englaro
R Vettor
Research01 Jul 1997
International Journal of Obesity

Volume: 21, P: 614-618
Roux-en-Y gastric bypass increases systemic but not portal bile acid concentrations by decreasing hepatic bile acid uptake in minipigs

O Chávez-Talavera
G Baud
F Pattou
Research17 Jan 2017
International Journal of Obesity

Volume: 41, P: 664-668
The nuclear receptor FXR inhibits Glucagon-Like Peptide-1 secretion in response to microbiota-derived Short-Chain Fatty Acids

Sarah Ducastel
Véronique Touche
Sophie Lestavel
ResearchOpen Access13 Jan 2020
Scientific Reports

Volume: 10, P: 1-10
Serum leptin levels in alcoholic liver cirrhosis: relationship with gender, nutritional status, liver function and energy metabolism

B Campillo
E Sherman
PN Bories
Research25 Oct 2001
European Journal of Clinical Nutrition

Volume: 55, P: 980-988
PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans

Vera H. W. de Wit-Verheggen
Vera B. Schrauwen-Hinderling
Tineke van de Weijer
ResearchOpen Access23 May 2023
Scientific Reports

Volume: 13, P: 1-10
Association between liver X receptor α gene polymorphisms and risk of metabolic syndrome in French populations

V Legry
D Cottel
A Meirhaeghe
Research22 Jan 2008
International Journal of Obesity

Volume: 32, P: 421-428
Ffar2 expression regulates leukaemic cell growth in vivo

Laure B Bindels
Paolo E Porporato
Nathalie M Delzenne
ResearchOpen Access05 Sept 2017
British Journal of Cancer

Volume: 117, P: 1336-1340
Influence of Roux-en-Y gastric bypass on plasma bile acid profiles: a comparative study between rats, pigs and humans

V Spinelli
F Lalloyer
A Tailleux
Research22 Mar 2016
International Journal of Obesity

Volume: 40, P: 1260-1267
Chronic palmitate exposure inhibits AMPKα and decreases glucose-stimulated insulin secretion from β-cells: modulation by fenofibrate

Ying Sun
Meng Ren
Jia-jun Zhao
Research01 Apr 2008
Acta Pharmacologica Sinica

Volume: 29, P: 443-450
Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity

Marion Régnier
Arnaud Polizzi
Alexandra Montagner
ResearchOpen Access16 Apr 2020
Scientific Reports

Volume: 10, P: 1-15
3D imaging of human organs with micrometer resolution - applied to the endocrine pancreas

Hahn et al. present a method to visualize the endocrine human pancreas in 3D and calculate volumetric data. Using immunolabeling to visualize targets of interest and in reconstructing large tissue parts from imaged cm3-sized tissue blocks, they use their method to reveal previously unknown morphological differences in the endocrine pancreas affected with type 2 diabetes.

Max Hahn
Christoffer Nord
Ulf Ahlgren
ResearchOpen Access10 Sept 2021
Communications Biology

Volume: 4, P: 1-10
Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes

R Dutia
M Embrey
B Laferrère
Research20 Jan 2015
International Journal of Obesity

Volume: 39, P: 806-813

Search

Peroxisome proliferator-activated receptors and inflammation: from basic science to clinical applications

Circadian rhythms influence surgical outcomes

Fibrates and future PPARα agonists in the treatment of cardiovascular disease

Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH

Erratum: Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes

Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease

Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution

Author Correction: Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution

Tenascin–X deficiency is associated with Ehlers–Danlos syndrome

Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Leptin increases circulating glucose, insulin and glucagon via sympathetic neural activation in fasted mice

Association of poorly controlled diabetes with low serum leptin in morbid obesity

Insulin induces rapid changes of plasma leptin in lean but not in genetically obese (fa/fa) rats

Roux-en-Y gastric bypass increases systemic but not portal bile acid concentrations by decreasing hepatic bile acid uptake in minipigs

The nuclear receptor FXR inhibits Glucagon-Like Peptide-1 secretion in response to microbiota-derived Short-Chain Fatty Acids

Serum leptin levels in alcoholic liver cirrhosis: relationship with gender, nutritional status, liver function and energy metabolism

PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans

Association between liver X receptor α gene polymorphisms and risk of metabolic syndrome in French populations

Ffar2 expression regulates leukaemic cell growth in vivo

Influence of Roux-en-Y gastric bypass on plasma bile acid profiles: a comparative study between rats, pigs and humans

Chronic palmitate exposure inhibits AMPKα and decreases glucose-stimulated insulin secretion from β-cells: modulation by fenofibrate

Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity

3D imaging of human organs with micrometer resolution - applied to the endocrine pancreas

Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes

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