Antibiotics target protein synthesis by binding and inhibiting key functional centers of the ribosome. Single-molecule imaging and X-ray crystallography studies now demonstrate that the aminoglycoside antibiotic neomycin binds to ribosomal RNA within the large subunit to allosterically control ribosomal subunit rotation and stabilize an inactive configuration of the ribosome.
- Leyi Wang
- Arto Pulk
- Scott C Blanchard