The attributes and endurance of the T cell responses following prime and boost doses are important measures of vaccine quality. Here authors show, by studying reactivation responses to a recombinant zoster vaccine for shingles, that glycoprotein E-specific memory CD4+ T cells respond strongly and with long-lasting expansion and activation, which are retained for at least a year.
- Xiaomin Wen
- Alex K. Hu
- William W. Kwok
