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Showing 1–12 of 12 results
Advanced filters: Author: BRADFORD N. WORTHINGTON Clear advanced filters

  • Bradford, Zhang and colleagues generate a mouse model harboring a mutation that impacts PKP2 splicing and show that one-time administration of AAV-PKP2 in neonatal mice could restore PKP2 and prevent the onset of key pathological features of arrhythmogenic right ventricular cardiomyopathy, and one-time administration in adult mice could rescue the phenotype and prevent sudden death up to 4 months post treatment.

    • William H. Bradford
    • Jing Zhang
    • Farah Sheikh
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 2, P: 1246-1261

  • Analysis of 10,900 whole-exome sequences linked to electronic health care records in the Penn Medicine Biobank enabled an exome-wide study of the phenotypic effects of rare loss-of-function gene variants, identifying new gene–disease associations that replicated across other biobanks.

    • Joseph Park
    • Anastasia M. Lucas
    • Daniel J. Rader
    Research
    Nature Medicine
    Volume: 27, P: 66-72

  • Myofibroblast differentiation contributes to extracellular matrix remodeling and fibrosis. Here, the authors report that alterations in mitochondrial calcium uptake is essential for metabolic reprogramming and epigenetic signaling for activation of the myofibroblast gene program.

    • Alyssa A. Lombardi
    • Andrew A. Gibb
    • John W. Elrod
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • The newly identified calsyntenin 3β protein has a role in the innervation of thermogenic fat through a mechanism of communication—which is unique to mammals—between thermogenic adipocytes and sympathetic neurons.

    • Xing Zeng
    • Mengchen Ye
    • Bruce M. Spiegelman
    Research
    Nature
    Volume: 569, P: 229-235

  • Physiological matching of blood flow to the demand for oxygen by the heart is required for sustained cardiac health, yet the underlying mechanisms are obscure. Here, the authors report a key role for acute modifications to the redox state of intracellular pyridine nucleotides in coronary smooth muscle and their impact on voltage-gated K + channels in metabolic vasodilation

    • Marc M. Dwenger
    • Sean M. Raph
    • Matthew A. Nystoriak
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Water within glaciers and ice sheets has a strong potential to influence ice velocity and, ultimately, the rate of sea-level rise. But so far direct measurement of the magnitude and characteristics of water stored within glaciers has proved difficult. Here, a combination of in situ borehole measurements and radar and seismic imaging has been used to show that there is an extensive network of basal crevasses in the Bench Glacier in Alaska. The crevasses hold water equivalent to at least a decimetre layer.

    • Joel T. Harper
    • John H. Bradford
    • Toby W. Meierbachtol
    Research
    Nature
    Volume: 467, P: 579-582

  • The nature of the retinal cell-type-specific circuitry that predisposes to retinoblastoma is demonstrated, in which a program that is unique to post-mitotic human cone precursors sensitizes to the oncogenic effects of retinoblastoma (Rb) protein depletion; hence, the loss of Rb collaborates with the molecular framework of cone precursors to initiate tumorigenesis.

    • Xiaoliang L. Xu
    • Hardeep P. Singh
    • David Cobrinik
    Research
    Nature
    Volume: 514, P: 385-388