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A myelin-related transcriptomic profile is shared by Pitt–Hopkins syndrome models and human autism spectrum disorder

The authors identify an impaired myelination signature from the brains of mouse models of Pitt–Hopkins syndrome and show that it is shared in the postmortem brains of people with autism.

BaDoi N. Phan
Joseph F. Bohlen
Brady J. Maher
Research03 Feb 2020
Nature Neuroscience

Volume: 23, P: 375-385
Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of distinct inhibitory interneuron subtypes

Huei-Ying Chen
BaDoi N. Phan
Brady J. Maher
Research28 Sept 2023
Molecular Psychiatry

Volume: 28, P: 4679-4692
Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder

Dysfunction in dorsal striatum, a brain region important for reward and habits, is linked to opioid use disorder (OUD). Here, authors delineate diverse cell populations in human dorsal striatum, revealing altered inflammatory and DNA damage signaling in OUD.

BaDoi N. Phan
Madelyn H. Ray
Ryan W. Logan
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-19
Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

Here, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocytes results in mutually synergistic maturation.

Emily E. Burke
Joshua G. Chenoweth
Andrew E. Jaffe
ResearchOpen Access23 Jan 2020
Nature Communications

Volume: 11, P: 1-14
Molecular rhythm alterations in prefrontal cortex and nucleus accumbens associated with opioid use disorder

Xiangning Xue
Wei Zong
Ryan W. Logan
ResearchOpen Access26 Mar 2022
Translational Psychiatry

Volume: 12, P: 1-13

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A myelin-related transcriptomic profile is shared by Pitt–Hopkins syndrome models and human autism spectrum disorder

Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of distinct inhibitory interneuron subtypes

Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

Molecular rhythm alterations in prefrontal cortex and nucleus accumbens associated with opioid use disorder

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