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Intrinsic temperature increase drives lipid metabolism towards ferroptosis evasion and chemotherapy resistance in pancreatic cancer

The development of cancer is typically accompanied by changes in the tumor microenvironment that support tumor growth and affect therapy response. Here, the authors show that increased intratumoral temperature is an inherent feature of human pancreatic cancer and contributes to therapy resistance by altering the lipid content of the tumor.

Vincent de Laat
Halit Topal
Johannes V. Swinnen
ResearchOpen Access02 Oct 2024
Nature Communications

Volume: 15, P: 1-11
PD-1^- CD45RA⁺ effector-memory CD8 T cells and CXCL10⁺ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma

Although atezolizumab and bevacizumab have changed the treatment landscape of advanced hepatocellular carcinoma, the factors that determine responsiveness to treatment remain unclear. Using single-cell RNA sequencing, the authors identify specific macrophage and T cell subsets that are enriched in patients with durable responses.

Sarah Cappuyns
Gino Philips
Jeroen Dekervel
ResearchOpen Access29 Nov 2023
Nature Communications

Volume: 14, P: 1-17
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer

Mazzone and colleagues identify the bicarbonate transporter SLC4A4 as highly abundant in epithelial duct cells in pancreatic cancer and show that its inhibition mitigates acidosis in the tumor, thereby alleviating immune suppression and overcoming immunotherapy resistance.

Federica Cappellesso
Marie-Pauline Orban
Massimiliano Mazzone
ResearchOpen Access15 Dec 2022
Nature Cancer

Volume: 3, P: 1464-1483
Role of cancer stem cells in pancreatic ductal adenocarcinoma

With greater understanding of the biology of pancreatic cancer a role for cancer stem cells is becoming clear. The authors of this Review discuss the current knowledge on pancreatic cancer stem cells and their potential use as targets in therapeutic regimens.

Gregory Sergeant
Hugo Vankelecom
Baki Topal
Reviews18 Aug 2009
Nature Reviews Clinical Oncology

Volume: 6, P: 580-586
Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk, promoting immunosuppression and immunotherapy resistance

Scolaro et al. identify the enzyme cytidine deaminase (CDA) as upregulated in immunotherapy-resistant tumors and find it contributes to the UDP pool, which in turn modulates tumor-associated macrophages to instruct an immune-evasive TME.

Tommaso Scolaro
Marta Manco
Massimiliano Mazzone
ResearchOpen Access06 Jun 2024
Nature Cancer

Volume: 5, P: 1206-1226
Histopathological growth patterns and tumor-infiltrating lymphocytes in breast cancer liver metastases

Sophia Leduc
Maxim De Schepper
Christine Desmedt
ResearchOpen Access15 Dec 2023
npj Breast Cancer

Volume: 9, P: 1-11

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Intrinsic temperature increase drives lipid metabolism towards ferroptosis evasion and chemotherapy resistance in pancreatic cancer

PD-1- CD45RA+ effector-memory CD8 T cells and CXCL10+ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma

Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer

Role of cancer stem cells in pancreatic ductal adenocarcinoma

Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk, promoting immunosuppression and immunotherapy resistance

Histopathological growth patterns and tumor-infiltrating lymphocytes in breast cancer liver metastases

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PD-1^- CD45RA⁺ effector-memory CD8 T cells and CXCL10⁺ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma