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Circular RNA-based protein replacement therapy mitigates osteoarthritis in male mice

In vitro transcribed circular RNAs (ivcRNAs) offer a stable and efficient platform for protein replacement therapy. Here, the authors show that localized ivcRNA delivery restores MSI2 and SOX5 expression in chondrocytes, mitigating osteoarthritis progression in mice.

Jinlong Suo
Ling Li
Weiguo Zou
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-16
Leveraging base excision repair for efficient adenine base editing of mitochondrial DNA

Understanding base excision repair leads to the development of more efficient mitochondrial adenine editors.

Yuhang Fan
Wenchao Xu
Jia Chen
Research25 Mar 2025
Nature Biotechnology

P: 1-14
Author Correction: CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells

Liang-Zhong Yang
Yi-Hui Min
Ling-Ling Chen
Amendments and Corrections02 Aug 2024
Nature Methods

Volume: 21, P: 1958
Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure

Prime editors can mediate all twelve types of base substitutions and small insertions or deletions in living cells but its efficiency remains low. Here the authors introduce same-sense mutations into pegRNAs to increase base-editing efficiency and the pegRNA secondary structure was altered to increase indel-editing efficiency.

Xiaosa Li
Lina Zhou
Jia Chen
ResearchOpen Access29 Mar 2022
Nature Communications

Volume: 13, P: 1-9
CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells

This work introduces CRISPRdelight, a dCas12a-based DNA-imaging tool that facilitates the imaging of non-repetitive loci and the tracking of DNA dynamics.

Liang-Zhong Yang
Yi-Hui Min
Ling-Ling Chen
Research04 Jul 2024
Nature Methods

Volume: 21, P: 1646-1657
Design and application of the transformer base editor in mammalian cells and mice

The authors describe a new base editing system—the transformer base editor—to induce efficient editing with no observable genome-wide or transcriptome-wide off-target mutations, both in mammalian cells and in mice.

Wenyan Han
Bao-Qing Gao
Jia Chen
Protocols04 Oct 2023
Nature Protocols

Volume: 18, P: 3194-3228
Effective protective mechanisms of HO-1 in diabetic complications: a narrative review

Jing-jing Zhang
Ping Ni
Bao-qing Zhao
ReviewsOpen Access10 Oct 2024
Cell Death Discovery

Volume: 10, P: 1-18

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Circular RNA-based protein replacement therapy mitigates osteoarthritis in male mice

Leveraging base excision repair for efficient adenine base editing of mitochondrial DNA

Author Correction: CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells

Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure

CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells

Design and application of the transformer base editor in mammalian cells and mice

Effective protective mechanisms of HO-1 in diabetic complications: a narrative review

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