α2δ1 is a marker of liver tumour-initiating cells. Here the authors show that PBX3 is necessary and sufficient for tumour initiation by α2δ1+ cells by regulating transcription of stemness genes, and that PBX3 is targeted by four miRNAs downregulated in α2δ1+ cells.
- Haibo Han
- Yantao Du
- Zhiqian Zhang
