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Mycobacterium tuberculosis-derived linoleic acid increases regulatory T cell function to promote bacterial survival within macrophages

Mycobacterium tuberculosis produces linoleic acid, which is released from macrophages during infection and upregulates regulatory T cell activity, to suppress macrophage control of intracellular bacteria in mice.

Hongyu Cheng
Shenzhi Li
Baoxue Ge
Research10 Oct 2025
Nature Microbiology

P: 1-17
Mycobacterium tuberculosis produces d-serine under hypoxia to limit CD8⁺ T cell-dependent immunity in mice

Hypoxia induces d-serine production by Mycobacterium tuberculosis which inhibits mTORC1 and T-bet expression to restrict downstream CD8⁺ T cell immune responses and macrophage activation, and inhibit control of tuberculosis in mice.

Hongyu Cheng
Zhe Ji
Baoxue Ge
ResearchOpen Access28 May 2024
Nature Microbiology

Volume: 9, P: 1856-1872
Host-mediated ubiquitination of a mycobacterial protein suppresses immunity

Mycobacterium tuberculosis suppresses the production of inflammatory cytokines by host cells through the host-mediated ubiquitination of a mycobacterial protein, enhancing the interaction of a host signalling inhibitor with another signalling molecule.

Lin Wang
Juehui Wu
Baoxue Ge
Research15 Jan 2020
Nature

Volume: 577, P: 682-688
MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy

How Mycobacterium tuberculosis (Mtb) escapes autophagy-mediated clearance is poorly understood. Here, Liu et al. show that Mtb-induced MicroRNA-27a targets the ER-associated calcium transporter CACNA2D3, leading to suppression of antimicrobial autophagy and to enhanced intracellular survival of Mtb.

Feng Liu
Jianxia Chen
Baoxue Ge
ResearchOpen Access16 Oct 2018
Nature Communications

Volume: 9, P: 1-14
Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine

In this work, authors mechanistically investigate the reduced induction of antimicrobial peptides in Mycobacterium tuberculosis infected macrophages.

Cheng Peng
Yuanna Cheng
Lin Wang
ResearchOpen Access17 May 2024
Nature Communications

Volume: 15, P: 1-19
PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1

Phospholipase C β (PLCβ) exhibits immuno-modulatory functions but its role in antiviral innate responses is unclear. Here, the authors provide evidence that PLCβ2 down regulates enterovirus-induced pro-inflammatory responses via inhibition of TAK1 activation, and suggest PLC as a potential therapeutic target.

Lin Wang
Yilong Zhou
Baoxue Ge
ResearchOpen Access14 Feb 2019
Nature Communications

Volume: 10, P: 1-13
Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters

Here, authors present cryo-EM structures and simulations of urea transporter members in resting-, transport-, or inactive-states bound with synthetic competitive, uncompetitive or noncompetitive inhibitor.

Shen-Ming Huang
Zhi-Zhen Huang
Jin-Peng Sun
ResearchOpen Access26 Nov 2024
Nature Communications

Volume: 15, P: 1-17
Ifnar gene variants influence gut microbial production of palmitoleic acid and host immune responses to tuberculosis

Chen et al. show how host genetics influence the abundance of commensal Akkermansia muciniphila in the gut, which in turn produce palmitoleic acid, thus contributing to shaping host immune responses to Mycobacterium tuberculosis infection.

Lingming Chen
Guoliang Zhang
Gucheng Zeng
Research14 Mar 2022
Nature Metabolism

Volume: 4, P: 359-373
Oxidization of TGFβ-activated kinase by MPT53 is required for immunity to Mycobacterium tuberculosis

Mycobacterium tuberculosis secreted protein MPT53 mediates the activation of TAK1 and induces the host immune inflammatory response.

Lin Wang
Zhonghua Liu
Baoxue Ge
Research20 May 2019
Nature Microbiology

Volume: 4, P: 1378-1388
The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3

Type I interferons suppress viral infection. Ge and colleagues show that the kinase CK1ɛ contributes to this innate immune response by phosphorylating the signaling adaptor TRAF3 to facilitate the expression of type I interferons.

Yilong Zhou
Chenxi He
Baoxue Ge
Research29 Feb 2016
Nature Immunology

Volume: 17, P: 397-405
Low molecular weight fucoidan protects renal tubular cells from injury induced by albumin overload

Yingli Jia
Yi Sun
Baoxue Yang
ResearchOpen Access22 Aug 2016
Scientific Reports

Volume: 6, P: 1-10
Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese

Genetic risk loci for tuberculosis (TB) have so far been identified in African and Russian populations. Here, the authors perform a three-stage GWAS for TB in Han Chinese populations and find two risk loci near ESRRB and TGM6 and further demonstrate that tgm6 protects mice from Mtb infection.

Ruijuan Zheng
Zhiqiang Li
Baoxue Ge
ResearchOpen Access04 Oct 2018
Nature Communications

Volume: 9, P: 1-9
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

DNA damage induces translocation of cyclic GMP–AMP synthase to the nucleus, where it suppresses homologous recombination by interfering with the formation of the PARP1–Timeless complex.

Haipeng Liu
Haiping Zhang
Baoxue Ge
Research24 Oct 2018
Nature

Volume: 563, P: 131-136
Structural characterization of the urea transporter bound to the orally bioavailable inhibitor E3

Shen-ming Huang
Bo-yang Cai
Jin-peng Sun
Research16 Jun 2025
Acta Pharmacologica Sinica

P: 1-9
RING1 dictates GSDMD-mediated inflammatory response and host susceptibility to pathogen infection

Yuanyuan Li
Wenqing Gao
Jixi Li
Research14 May 2025
Cell Death & Differentiation

P: 1-12
Developing Hypothetical Inhibition Mechanism of Novel Urea Transporter B Inhibitor

Min Li
Weng Ieong Tou
Baoxue Yang
ResearchOpen Access22 Jul 2014
Scientific Reports

Volume: 4, P: 1-12
Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilatation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway

Yi Sun
Chi-Wai Lau
Baoxue Yang
ResearchOpen Access07 Jan 2016
Scientific Reports

Volume: 6, P: 1-14
Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress

Dandan Zhong
Hongkai Wang
Baoxue Yang
ResearchOpen Access25 Nov 2015
Scientific Reports

Volume: 5, P: 1-14
Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity

Hua Yang
Fei Wang
Baoxue Ge
ResearchOpen Access05 Oct 2021
Cell Discovery

Volume: 7, P: 1-18
Ganoderic acid A is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease

Jia Meng
Sai-zhen Wang
Bao-xue Yang
Research07 Jan 2020
Acta Pharmacologica Sinica

Volume: 41, P: 782-790
A new generation M^pro inhibitor with potent activity against SARS-CoV-2 Omicron variants

Chong Huang
Huiping Shuai
Shengyong Yang
ResearchOpen Access16 Mar 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-13
Mycobacterium tuberculosis inhibits METTL14-mediated m⁶A methylation of Nox2 mRNA and suppresses anti-TB immunity

Mingtong Ma
Yongjia Duan
Baoxue Ge
ResearchOpen Access29 Mar 2024
Cell Discovery

Volume: 10, P: 1-23
1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia

Xiao-wei Li
Jian-hua Ran
Bao-xue Yang
Research29 Jul 2022
Acta Pharmacologica Sinica

Volume: 44, P: 406-420
Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor

Abudumijiti Abulizi
Ling Hu
Bao-xue Yang
Research29 Apr 2021
Acta Pharmacologica Sinica

Volume: 42, P: 1703-1713
A thienopyridine, CB-20, exerts diuretic activity by inhibiting urea transporters

Min Li
Yan Zhao
Bao-xue Yang
Research18 Jun 2019
Acta Pharmacologica Sinica

Volume: 41, P: 65-72
Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

Xiao-qiang Geng
Ang Ma
Bao-xue Yang
Research05 Dec 2019
Acta Pharmacologica Sinica

Volume: 41, P: 670-677
Phenylphthalazines as small-molecule inhibitors of urea transporter UT-B and their binding model

Jian-hua Ran
Min Li
Bao-xue Yang
Research30 May 2016
Acta Pharmacologica Sinica

Volume: 37, P: 973-983
High doses of α-galactosylceramide potentiate experimental autoimmune encephalomyelitis by directly enhancing Th17 response

Gaochao Qian
Xia Qin
Jingwu Z. Zhang
Research19 Jan 2010
Cell Research

Volume: 20, P: 480-491
Drug discovery for polycystic kidney disease

Ying Sun
Hong Zhou
Bao-xue Yang
Reviews03 Jun 2011
Acta Pharmacologica Sinica

Volume: 32, P: 805-816

Search

Mycobacterium tuberculosis-derived linoleic acid increases regulatory T cell function to promote bacterial survival within macrophages

Mycobacterium tuberculosis produces d-serine under hypoxia to limit CD8⁺ T cell-dependent immunity in mice

Host-mediated ubiquitination of a mycobacterial protein suppresses immunity

MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy

Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine

PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1

Structural insights into the mechanisms of urea permeation and distinct inhibition modes of urea transporters

Ifnar gene variants influence gut microbial production of palmitoleic acid and host immune responses to tuberculosis

Oxidization of TGFβ-activated kinase by MPT53 is required for immunity to Mycobacterium tuberculosis

The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3

Low molecular weight fucoidan protects renal tubular cells from injury induced by albumin overload

Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

Structural characterization of the urea transporter bound to the orally bioavailable inhibitor E3

RING1 dictates GSDMD-mediated inflammatory response and host susceptibility to pathogen infection

Developing Hypothetical Inhibition Mechanism of Novel Urea Transporter B Inhibitor

Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilatation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway

Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress

Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity

Ganoderic acid A is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease

A new generation M^pro inhibitor with potent activity against SARS-CoV-2 Omicron variants

Mycobacterium tuberculosis inhibits METTL14-mediated m⁶A methylation of Nox2 mRNA and suppresses anti-TB immunity

1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia

Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor

A thienopyridine, CB-20, exerts diuretic activity by inhibiting urea transporters

Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

Phenylphthalazines as small-molecule inhibitors of urea transporter UT-B and their binding model

High doses of α-galactosylceramide potentiate experimental autoimmune encephalomyelitis by directly enhancing Th17 response

Drug discovery for polycystic kidney disease

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