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Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases

Elevated ceramides have been implicated in endothelial dysfunction, preceding cardiometabolic diseases. Yet, direct in vivo evidence is lacking. Here we show that suppression of ceramides and S1P are causally linked to endothelial dysfunction contributing to cardiometabolic disease in obese mice

Luisa Rubinelli
Onorina Laura Manzo
Annarita Di Lorenzo
ResearchOpen Access25 Feb 2025
Nature Communications

Volume: 16, P: 1-14
Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity

MC4R colocalizes with ADCY3 at primary cilia in hypothalamic neurons, and MC4R mutations associated with human obesity impair this localization. Inhibition of adenylyl cyclase signaling at primary cilia of neurons leads to increased body weight in mice.

Jacqueline E. Siljee
Yi Wang
Christian Vaisse
Research08 Jan 2018
Nature Genetics

Volume: 50, P: 180-185
Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR

Different key residues mediate melanocortin-4 receptor activation via the agonist αMSH or constitutive activation via interaction of the transmembrane domain with the N-terminal domain, and these modes are further distinguishable by the different effects of the physiological antagonist.

Baran A Ersoy
Leonardo Pardo
Christian Vaisse
Research24 Jun 2012
Nature Chemical Biology

Volume: 8, P: 725-730
Impact of host switching at different larval instars on the performance of the polyphagous pest Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae)

Baran Aslan
Ali Kemal Birgücü
Ebru Gül Aslan
ResearchOpen Access28 Mar 2025
Scientific Reports

Volume: 15, P: 1-9
Mutational Analysis of the Pro-opiomelanocortin Gene in French Obese Children Led to the Identification of a Novel Deleterious Heterozygous Mutation Located in the α-Melanocyte Stimulating Hormone Domain

Beatrice Dubern
Cecile Lubrano-Berthelier
Karine Clement
Research01 Feb 2008
Pediatric Research

Volume: 63, P: 211-216

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Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity

Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR

Impact of host switching at different larval instars on the performance of the polyphagous pest Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae)

Mutational Analysis of the Pro-opiomelanocortin Gene in French Obese Children Led to the Identification of a Novel Deleterious Heterozygous Mutation Located in the α-Melanocyte Stimulating Hormone Domain

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