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Showing 1–3 of 3 results
Advanced filters: Author: Barani Kumar Rajendran Clear advanced filters

  • CD8 + T cells are central players in anti-tumour immunity. Here authors identify Cul5, a ubiquitin E3 ligase as an important inhibitor of CD8 + T cell anti-tumour cytotoxicity and persistence via involvement with both T cell receptor and cytokine-regulated central pathways.

    • Xiaofeng Liao
    • Wenxue Li
    • Dianqing Wu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Nasopharyngeal carcinoma (NPC) is a malignant cancer type with high morbidity in Asia, and its current molecular classification is insufficient to predict therapy outcomes. Here the authors explore NPC subtype-specific response to therapy with a pharmacogenomics strategy integrating genomics and drug response of patient-derived organoids.

    • Ren-Bo Ding
    • Ping Chen
    • Chu-Xia Deng
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • BRCA1 mutation carriers have higher chances of developing triple-negative breast cancer (TNBC). Here, the authors use the Sleeping Beauty mutagenesis system in Brca1 deficient mice and identify 169 putative driver genes, of which NOTCH1 accelerates TNBC formation through promoting epithelial-mesenchymal transition and cell cycle progression.

    • Kai Miao
    • Josh Haipeng Lei
    • Chu-Xia Deng
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15