Self-assembling peptides have broad biomedical relevance, but the relationship between molecular properties of monomers, intermediates and the supramolecular assembly process remains somewhat elusive. Here, studies of fibril-forming surfactant-like peptides with different β-sheet propensities and charged residues show that the amount of formed peptide nanofibers is defined by oligomeric nucleation propensities.
- Chun Yin Jerry Lau
- Federico Fontana
- Enrico Mastrobattista
