The ideal in organic synthesis is to prepare complex molecules using the smallest possible number of steps. Also important is atom economy, limiting waste by ensuring that most of atoms present in the reactants end up in the product. This paper demonstrates both of these principles to great effect in the synthesis of bryostatin 16, a biologically active, naturally occurring compound. The synthesis uses nearly half the number of steps of previously reported routes to bryostatins.
- Barry M. Trost
- Guangbin Dong
