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Showing 1–2 of 2 results
Advanced filters: Author: Bart Kanon Clear advanced filters

  • Ruth Loos and colleagues report a meta-analysis of genome-wide association studies in 181,171 individuals identifying 14 new loci associated with heart rate and test these for association with cardiac conduction, rhythm disorders and cardiovascular disease. Their experimental studies in Drosophila melanogaster and zebrafish models provide support for a role for 20 candidate genes at 11 of these loci in regulation of heart rate.

    • Marcel den Hoed
    • Mark Eijgelsheim
    • Ruth J F Loos
    Research
    Nature Genetics
    Volume: 45, P: 621-631

  • Cellular use of coenzyme A from external sources requires the hydrolysis of extracellular coenzyme A into 4′-phosphopanthetheine, which can cross the membrane. CoA synthase subsequently converts intracellular 4′-phosphopanthetheine into coenzyme A.

    • Balaji Srinivasan
    • Madina Baratashvili
    • Ody C M Sibon
    Research
    Nature Chemical Biology
    Volume: 11, P: 784-792