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Showing 1–4 of 4 results
Advanced filters: Author: Bartosz Tarkowski Clear advanced filters

  • Upon intramuscular administration, COVID-19 mRNA vaccines are primarily taken up by macrophages, in which the cellular machinery extends their poly(A) tails, thereby increasing mRNA stability and translation, providing an explanation for the efficacy of these vaccines.

    • Paweł S. Krawczyk
    • Michał Mazur
    • Seweryn Mroczek
    ResearchOpen Access
    Nature
    Volume: 641, P: 984-992

  • The kinase RAF1 usually exerts pro-tumorigenic functions promoting proliferation in RAS-driven cancers. Here, the authors using a mouse model of HCC and clinical data describe an unexpected oncosuppressor role of RAF1 in hepatocarcinoma development linked to a gp130-dependent Stat3 activation and YAP1 regulation.

    • Ines Jeric
    • Gabriele Maurer
    • Manuela Baccarini
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Regulating polyadenylation is important for mRNA stability, which can in turn affect B cell maturation and humoral immune responses. Here the authors use Nanopore poly(A) sequencing to explore the importance of the cytoplasmic poly(A) polymerase TENT5C, particularly in the production of immunoglobulins.

    • Aleksandra Bilska
    • Monika Kusio-Kobiałka
    • Seweryn Mroczek
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17