Nature Search

Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity

This study investigates the developmental transcriptional regulation of mitochondrial quality control. Authors identify the Drosophila factor Mirana, homologous to mammalian TZAP, as a key temporal regulator of mitochondrial morphology and function, critical for activity-dependent synaptic connectivity.

Iryna Mohylyak
Maheva Andriatsilavo
Bassem A. Hassan
ResearchOpen Access01 Sept 2025
Nature Communications

Volume: 16, P: 1-19
Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors

Notch inhibitors result in the differentiation of intestinal crypt progenitors into goblet cells, suggesting that they could be of use in treating intestinal neoplasia. Here van Eset al. show that Math1 is required for intestinal cell differentiation induced by Notch inhibition.

Johan H. van Es
Natalie de Geest
Bassem A. Hassan
ResearchOpen Access17 May 2010
Nature Communications

Volume: 1, P: 1-5
Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster

The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in stereotyped neuronal circuits.

Maheva Andriatsilavo
Carolina Barata
Bassem A. Hassan
Research07 May 2025
Nature Neuroscience

Volume: 28, P: 998-1011
Author Correction: Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair

Jean-Baptiste Huré
Louis Foucault
Carlos Parras
Amendments and CorrectionsOpen Access09 Jan 2025
Nature Communications

Volume: 16, P: 1
Hamlet Notches fate

Cell specification of olfactory receptor neurons in Drosophila is orchestrated by context-dependent response to Notch signaling mediated by Hamlet, which directs specific chromatin modifications in subsets of neurons.

Dietmar Schmucker
Bassem A Hassan
News & Views26 Jan 2012
Nature Neuroscience

Volume: 15, P: 174-176
Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair

Effective treatments for myelin repair are currently lacking. Here, the authors show that two FDA-approved drugs, leucovorin and dyclonine, identified through pharmacogenomic screening, promote oligodendrocyte formation and brain repair in myelin injury models.

Jean-Baptiste Huré
Louis Foucault
Carlos Parras
ResearchOpen Access13 Nov 2024
Nature Communications

Volume: 15, P: 1-24
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures

The genomic sequences of 12 Drosophila species for conserved elements and describe the relationship between conservation and function for many specific sequence motifs.

Alexander Stark
Michael F. Lin
Manolis Kellis
Research08 Nov 2007
Nature

Volume: 450, P: 219-232
Whole-brain annotation and multi-connectome cell typing of Drosophila

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

Philipp Schlegel
Yijie Yin
Gregory S. X. E. Jefferis
ResearchOpen Access02 Oct 2024
Nature

Volume: 634, P: 139-152
Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring

The molecular mechanisms that restrict synapse formation with incorrect partners remain unclear. Here, authors use 4D imaging in developing Drosophila brains to show that filopodial kinetics are regulated by autophagy and this restricts inappropriate partner choice through a process of kinetic exclusion

Ferdi Ridvan Kiral
Gerit Arne Linneweber
Peter Robin Hiesinger
ResearchOpen Access12 Mar 2020
Nature Communications

Volume: 11, P: 1-14
Rock typing and reservoir characterization of the Messinian Abu Madi Formation in the onshore South Abu El Naga Gas Field, Nile Delta, Egypt

Ahmed W. Al-Shareif
Mohamed A. Khalifa
Noha M. Hassan
ResearchOpen Access07 May 2025
Scientific Reports

Volume: 15, P: 1-23
A neuroscientific approach to increase gender equality

Christiane Schreiweis
Emmanuelle Volle
Violetta Zujovic
Correspondence30 Sept 2019
Nature Human Behaviour

Volume: 3, P: 1238-1239
Neuronal wiring diagram of an adult brain

FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosystem to facilitate exploration and browsing.

Sven Dorkenwald
Arie Matsliah
Meet Zandawala
ResearchOpen Access02 Oct 2024
Nature

Volume: 634, P: 124-138
Gene prioritization through genomic data fusion

Stein Aerts
Diether Lambrechts
Yves Moreau
Research05 May 2006
Nature Biotechnology

Volume: 24, P: 537-544
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

Stein Aerts, Jan Cools and colleagues report exome sequencing of T-cell acute lymphoblastic leukemia. They identify recurrent somatic mutations in CNOT3 and ribosome genes RPL5 and RPL10.

Kim De Keersmaecker
Zeynep Kalender Atak
Jan Cools
Research23 Dec 2012
Nature Genetics

Volume: 45, P: 186-190
Vitamin D alleviates lead induced renal and testicular injuries by immunomodulatory and antioxidant mechanisms in rats

Mohammad A. BaSalamah
Abdelghany Hassan Abdelghany
Bassem Refaat
ResearchOpen Access19 Mar 2018
Scientific Reports

Volume: 8, P: 1-13
Association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Egyptian children and adolescents

Naglaa F. Boraey
Marwa A. Bebars
Mohammed K. Haridi
ResearchOpen Access04 Jan 2024
Pediatric Research

Volume: 96, P: 1347-1354

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Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors

Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster

Author Correction: Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair

Hamlet Notches fate

Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair

Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures

Whole-brain annotation and multi-connectome cell typing of Drosophila

Autophagy-dependent filopodial kinetics restrict synaptic partner choice during Drosophila brain wiring

Rock typing and reservoir characterization of the Messinian Abu Madi Formation in the onshore South Abu El Naga Gas Field, Nile Delta, Egypt

A neuroscientific approach to increase gender equality

Neuronal wiring diagram of an adult brain

Gene prioritization through genomic data fusion

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

Vitamin D alleviates lead induced renal and testicular injuries by immunomodulatory and antioxidant mechanisms in rats

Association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Egyptian children and adolescents

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