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Showing 1–3 of 3 results
Advanced filters: Author: Beata Zamlynny Clear advanced filters

  • Agonists of the orexin receptor 2 (OX2R) show promise in the treatment of narcolepsy. Cryo-EM structures of active-state OX2R bound to an endogenous peptide agonist and a small-molecule agonist suggest a molecular mechanism that rationalizes both receptor activation and inhibition.

    • Chuan Hong
    • Noel J. Byrne
    • Kaspar Hollenstein
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Human leukotriene B4 receptors (BLT1 and BLT2) are members of the GPCR superfamily that respond to a potent pro-inflammatory lipid and chemoattractant LTB4. Here authors determined a crystal structure of the human BLT1 in complex with a selective antagonist MK-D-046 and provide insights into hBLT1 ligand recognition and its mechanism of action.

    • Nairie Michaelian
    • Anastasiia Sadybekov
    • Vadim Cherezov
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Crystal structures of two complexes of the angiotensin II receptor AT2R with distinct tightly bound ligands reveal an active-like state of the receptor, in which helix VIII adopts a non-canonical position that blocks binding of G proteins and β-arrestins.

    • Haitao Zhang
    • Gye Won Han
    • Vadim Cherezov
    Research
    Nature
    Volume: 544, P: 327-332