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Showing 1–3 of 3 results
Advanced filters: Author: Beate Eckes Clear advanced filters

  • Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring. Here the authors describe membrane permeable peptides that target the interface of TANGO1 and cTAGE5, inhibit secretion of ECM components and could be of therapeutic benefit during wound healing and fibrotic processes.

    • Ishier Raote
    • Ann-Helen Rosendahl
    • Vivek Malhotra
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Uncontrolled activation of fibroblasts contributes to tissue fibrosis and organ dysfunction. Here the authors demonstrate that the epigenetic control of autophagy is disturbed by a TGFβ-dependent downregulation of MYST1 in systemic sclerosis patients. Restoration of the epigenetic control of autophagy reduces fibroblast activation and ameliorates fibrotic tissue remodeling.

    • Ariella Zehender
    • Yi-Nan Li
    • Jörg H. W. Distler
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19