Nature Search

Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes

Ana Ferrer
Silvia Marcé
Dolors Colomer
Research11 Oct 2004
Oncogene

Volume: 23, P: 8941-8949
Correction: Corrigendum: Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

Clara Montagut
Alba Dalmases
Joan Albanell
Amendments and Corrections07 Sept 2012
Nature Medicine

Volume: 18, P: 1445
Erratum: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Giulia Siravegna
Benedetta Mussolin
Alberto Bardelli
Amendments and Corrections07 Jul 2015
Nature Medicine

Volume: 21, P: 827
Correction: Corrigendum: B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

Irene Puga
Montserrat Cols
Andrea Cerutti
Amendments and Corrections21 Jan 2014
Nature Immunology

Volume: 15, P: 205
p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis

The failure of chemotherapy in colorectal cancer is currently unclear. Here, the authors show that upon sub-lethal dose of chemotherapy wild-type p53 colorectal cancers acquire a quiescence-like phenotype and a YAP-dependent fetal-like intestinal stem cell state associated with a higher metastatic activity and poor prognosis in patients.

Laura Solé
Teresa Lobo-Jarne
Lluís Espinosa
ResearchOpen Access23 May 2022
Nature Communications

Volume: 13, P: 1-15
Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics

The homeobox NKX2 family of transcriptional factors has been shown to regulate fundamental developmental processes. Here, the authors show that NKX2-3 is a bona fideoncogenic driver in marginal-zone B-cell lymphoma and that it promotes lymphomagenesis by shaping lymphocyte dynamics and promoting BCR signalling.

Eloy F. Robles
Maria Mena-Varas
Jose A. Martinez-Climent
ResearchOpen Access14 Jun 2016
Nature Communications

Volume: 7, P: 1-16
Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

By modeling acquired resistance to the EGFR antibody cetuximab in metastatic colorectal cancer, the authors identify a new mutation in the ectodomain of the receptor. The mutation is present in patient tumors after cetuximab therapy, confirming that it represents a clinically-relevant mechanism for therapy resistance. Moreover, the mutation does not affect the response to other EGFR antibodies, suggesting that if independently confirmed it may be a useful indicator to tailor anti-EGFR therapy.

Clara Montagut
Alba Dalmases
Joan Albanell
Research22 Jan 2012
Nature Medicine

Volume: 18, P: 221-223
Clinical utility gene card for: Hereditary thrombocythemia

Kais Hussein
Melanie Percy
Holger Cario
Research05 Jun 2013
European Journal of Human Genetics

Volume: 22, P: 293
Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer

Some colorectal cancer patients respond well to treatment with anti-EGFR antibodies, however response is almost invariably followed by acquired resistance. Here, the authors show that patients with shorter responses acquireRAS mutations, while those relapsing later preferentially develop mutations in the extracellular domain of EGFR.

Beth O. Van Emburgh
Sabrina Arena
Alberto Bardelli
ResearchOpen Access08 Dec 2016
Nature Communications

Volume: 7, P: 1-9
Impact of somatic gene mutations on the risk of thrombosis in myelofibrosis

Irene Pastor-Galán
Arturo Pereira
Juan Carlos Hernández-Boluda
Research30 Aug 2024
Leukemia

Volume: 38, P: 2483-2486
Biomarkers of palbociclib response in hormone receptor-positive advanced breast cancer from the PARSIFAL trial

Joan Albanell
Angelo Gámez Pozo
Antonio Llombart-Cussac
ResearchOpen Access20 Jun 2025
npj Breast Cancer

Volume: 11, P: 1-9
High-accuracy liquid biopsies

Ultra-deep sequencing of paired plasma-circulating free DNA and white blood cells allows the identification of tumor-derived somatic mutations with high accuracy by filtering out variants consistent with clonal hematopoiesis.

Beatriz Bellosillo
Clara Montagut
News & Views25 Nov 2019
Nature Medicine

Volume: 25, P: 1820-1821
B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

Follicular T cells provide help to B cells to elicit antibody responses. Cerutti and colleagues show that neutrophils provide help to marginal-zone B cells that produce T cell–independent antibodies.

Irene Puga
Montserrat Cols
Andrea Cerutti
Research25 Dec 2011
Nature Immunology

Volume: 13, P: 170-180
Evaluation of the host immune response assay SeptiCyte RAPID for potential triage of COVID-19 patients

Maria Milagro Montero
Max Hardy-Werbin
Juan Pablo Horcajada
ResearchOpen Access18 Jan 2023
Scientific Reports

Volume: 13, P: 1-11
Impact of treatment for adolescent and young adults with essential thrombocythemia and polycythemia vera

Yan Beauverd
Jean-Christophe Ianotto
Claire N Harrison
ResearchOpen Access12 Mar 2025
Leukemia

Volume: 39, P: 1135-1145
Multi-hit TET2 mutations as a differential molecular signature of oligomonocytic and overt chronic myelomonocytic leukemia

Nieves Garcia-Gisbert
Leonor Arenillas
Xavier Calvo
Research22 Oct 2022
Leukemia

Volume: 36, P: 2922-2926
High mortality rate in COVID-19 patients with myeloproliferative neoplasms after abrupt withdrawal of ruxolitinib

Tiziano Barbui
Alessandro Maria Vannucchi
Alessandro Rambaldi
Research07 Jan 2021
Leukemia

Volume: 35, P: 485-493
Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19

Tiziano Barbui
Valerio De Stefano
Alessandro Maria Vannucchi
ResearchOpen Access04 Feb 2021
Blood Cancer Journal

Volume: 11, P: 1-11
Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

By monitoring ctDNA, the authors reveal the dynamic adaption of clonal populations in colorectal cancer patients treated with anti-EGFR therapy, suggesting that therapeutic re-challenge may have some benefit.

Giulia Siravegna
Benedetta Mussolin
Alberto Bardelli
Research01 Jun 2015
Nature Medicine

Volume: 21, P: 795-801
Genomic characterization of patients with polycythemia vera developing resistance to hydroxyurea

Alberto Alvarez-Larrán
Alvaro Díaz-González
Juan Carlos Hernández-Boluda
ResearchOpen Access05 May 2020
Leukemia

Volume: 35, P: 623-627
Usefulness of p16^INK4a staining for managing histological high-grade squamous intraepithelial cervical lesions

Ester Miralpeix
Jordi Genovés
Ramon Carreras
Research14 Oct 2016
Modern Pathology

Volume: 30, P: 304-310
MultiCOVID: a multi modal deep learning approach for COVID-19 diagnosis

Max Hardy-Werbin
José Maria Maiques
Joan Gibert
ResearchOpen Access31 Oct 2023
Scientific Reports

Volume: 13, P: 1-9
In silico validation of RNA-Seq results can identify gene fusions with oncogenic potential in glioblastoma

Ainhoa Hernandez
Ana Maria Muñoz-Mármol
Carmen Balana
ResearchOpen Access24 Aug 2022
Scientific Reports

Volume: 12, P: 1-11
Long-term follow-up of recovered MPN patients with COVID-19

Tiziano Barbui
Alessandra Iurlo
Alessandro Rambaldi
CorrespondenceOpen Access16 Jun 2021
Blood Cancer Journal

Volume: 11, P: 1-4

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Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes

Correction: Corrigendum: Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

Erratum: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Correction: Corrigendum: B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis

Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics

Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

Clinical utility gene card for: Hereditary thrombocythemia

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer

Impact of somatic gene mutations on the risk of thrombosis in myelofibrosis

Biomarkers of palbociclib response in hormone receptor-positive advanced breast cancer from the PARSIFAL trial

High-accuracy liquid biopsies

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

Evaluation of the host immune response assay SeptiCyte RAPID for potential triage of COVID-19 patients

Impact of treatment for adolescent and young adults with essential thrombocythemia and polycythemia vera

Multi-hit TET2 mutations as a differential molecular signature of oligomonocytic and overt chronic myelomonocytic leukemia

High mortality rate in COVID-19 patients with myeloproliferative neoplasms after abrupt withdrawal of ruxolitinib

Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Genomic characterization of patients with polycythemia vera developing resistance to hydroxyurea

Usefulness of p16^INK4a staining for managing histological high-grade squamous intraepithelial cervical lesions

MultiCOVID: a multi modal deep learning approach for COVID-19 diagnosis

In silico validation of RNA-Seq results can identify gene fusions with oncogenic potential in glioblastoma

Long-term follow-up of recovered MPN patients with COVID-19

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