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Showing 1–15 of 15 results
Advanced filters: Author: Beatriz M.A. Fontoura Clear advanced filters

  • Alternative splicing of influenza A virus (IAV) M transcript is regulated by hnRNP K and NS1-BP, but mechanistic details are unknown. Here, Thompson et al. show how hnRNP K and NS1-BP bind M mRNA and that these proteins regulate splicing of host transcripts in both the absence and presence of IAV infection.

    • Matthew G. Thompson
    • Raquel Muñoz-Moreno
    • Kristen W. Lynch
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • miRNAs regulate a range of biological processes, including the immune response and viral infection. Here, the authors perform a genome-wide miRNA mimic screen and identify a miRNA induced by IRF3 during viral infection that regulates viral–host interactions.

    • Melanie L. Yarbrough
    • Ke Zhang
    • Beatriz M. A. Fontoura
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • Here, Bhat et al. show that Influenza A virus mRNAs are exported from the nucleus via the nucleoporin Tpr and the mRNA export complex TREX-2. These mRNAs have low exon number, high mean exon length, and low GC content. A 45-nucleotide RNA signal can mediate export via TREX-2.

    • Prasanna Bhat
    • Vasilisa Aksenova
    • Beatriz M. A. Fontoura
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • A screen for compounds that alleviate the inhibitory effect of influenza NS1 on host gene expression and suppress viral toxicity found naphthalimides that could upregulate REDD1, an mTORC1 inhibitor, revealing that viruses inhibit REDD1 to activate the mTORC1 pathway.

    • Miguel A Mata
    • Neal Satterly
    • Beatriz M A Fontoura
    Research
    Nature Chemical Biology
    Volume: 7, P: 712-719

  • Influenza virus utilizes splicing factors stored at nuclear speckles through an intranuclear trafficking pathway, which targets viral M1 mRNA to nuclear speckles to promote post-transcriptional splicing and then transports the spliced M2 mRNA from the nucleus.

    • Amir Mor
    • Alexander White
    • Beatriz M. A. Fontoura
    Research
    Nature Microbiology
    Volume: 1, P: 1-13

  • mRNAs export from the nucleus is thought to be regulated in part by three nucleoporins that comprise the nuclear basket, but whether and how distinct basket nucleoporins interact with the RNA export machinery is unclear. Here, the authors use rapid auxin-mediated degradation of basket nucleoporins Nup153, Nup50, and Tpr, and see that Tpr interacts with the TREX-2 mRNA export complex.

    • Vasilisa Aksenova
    • Alexandra Smith
    • Mary Dasso
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

    • Yuh Min Chook
    • Beatriz M. A. Fontoura
    • Michael P. Rout
    Comments & Opinion
    Nature Structural & Molecular Biology
    Volume: 25, P: 297-298

  • RNA-dependent DEAD-box ATPases (DDXs) regulate the dynamics of phase-separated organelles, with ATP-bound DDXs promoting phase separation, and ATP hydrolysis inducing compartment disassembly and RNA release.

    • Maria Hondele
    • Ruchika Sachdev
    • Karsten Weis
    Research
    Nature
    Volume: 573, P: 144-148