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Showing 1–4 of 4 results
Advanced filters: Author: Behzad Etemad Clear advanced filters

  • Understanding the heterogeneity of HIV infection, such as in persons with non-suppressible HIV-1 viremia despite adherence to antiretroviral treatment, is crucial to better tailor therapeutic interventions to abrogate HIV-1 persistence.

    • Abbas Mohammadi
    • Behzad Etemad
    • Jonathan Z. Li
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 3212-3223

  • Current HIV cure-focused clinical trials rely on analytic treatment interruption (ATI) to evaluate post-treatment control (PTC). Here, combining untargetted metabolomics and glycomics in two HIV clinical cohorts, in vitro assays, and machine learning, the authors identify and validate metabolic and glycomic biomarkers linked to inflammatory pathways and HIV latency reactivation associated with PTC, suggesting non-invasive biomarkers as an alternative to predict HIV remission.

    • Leila B. Giron
    • Clovis S. Palmer
    • Mohamed Abdel-Mohsen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • In this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correlates with severity of respiratory disease, inflammatory markers and predicted risk of death.

    • Jesse Fajnzylber
    • James Regan
    • Alex Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9