Nature Search

A single mutation may contribute to accelerated evolution of SARS-CoV-2 toward Omicron

Drivers of viral evolution in SARS-CoV-2 are insufficiently understood. In this study, the authors show how a key SARS-CoV-2 mutation, NSP4 T492I, is potentially responsible for accelerating genome evolution to develop adaptive variants (e.g. Omicron).

Xiaoyuan Lin
Zhou Sha
Zhenglin Zhu
ResearchOpen Access29 Jul 2025
Nature Communications

Volume: 16, P: 1-18
Vaginal microbiome and sexually-transmitted pathogens in Chinese reproductive-age women: a multicentre cross-sectional and longitudinal cohort study

Here, in a study of over 6,000 women across China, the authors show that Mycoplasma hominis infection strongly influences vaginal microbiota and is linked to higher risk of cervical lesions, highlighting its importance in women’s reproductive health.

Muxuan Chen
Cancan Qi
Hongwei Zhou
ResearchOpen Access14 Nov 2025
Nature Communications

Volume: 16, P: 1-14
SEPTIN2 suppresses an IFN-γ-independent, proinflammatory macrophage activation pathway

Interferon-gamma (IFN-γ) is an important but not exclusive proinflammatory mediator in macrophages. Here authors show that IFN-γ-independent macrophage autoactivation involves endoplasmic reticulum (ER) stress which in turn induces the GTP-binding protein Septin2 to limit inflammation via a negative feedback loop.

Beibei Fu
Yan Xiong
Haibo Wu
ResearchOpen Access17 Nov 2023
Nature Communications

Volume: 14, P: 1-19
IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection

Immunosuppression as a result of severe infection impairs pathogen clearance and can increase susceptibility to secondary infection. Here, the authors dissect how T cell aging and the thymic involution that occurs during this process contribute to immunosuppression and find a key role for IL-33.

Lei Xu
Chuan Wei
Xiaojun Chen
ResearchOpen Access12 Nov 2022
Nature Communications

Volume: 13, P: 1-17
Association analysis identifies new risk loci for congenital heart disease in Chinese populations

Genome-wide association studies in Chinese and Europeans have identified multiple loci associated with congenital heart disease. Here the authors use existing GWAS data to conduct an extended three-stage analysis in Han Chinese and identify four novel loci linked to disease risk in this population.

Yuan Lin
Xuejiang Guo
Zhibin Hu
Research18 Aug 2015
Nature Communications

Volume: 6, P: 1-7
Child-trafficking networks of illegal adoption in China

A social network analysis of over 20,000 reports of illegal child adoption in China reveals the most important cities, provinces and paths of child trafficking. Over 80% of the network can be reached by targeting four cities.

Zhen Wang
Liyuan Wei
Beibei Niu
Research15 May 2018
Nature Sustainability

Volume: 1, P: 254-260
Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival

Miaomiao Li
Wenjing Huang
Ping Chen
ResearchOpen Access11 Jun 2024
Cell Death & Disease

Volume: 15, P: 1-15
Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC

Longhao Wang
Tao Hu
Jie Zhao
ResearchOpen Access10 Nov 2022
Cell Death & Disease

Volume: 13, P: 1-16
A homozygous FANCM frameshift pathogenic variant causes male infertility

Hao Yin
Hui Ma
Qinghua Shi
ResearchOpen Access12 Jun 2018
Genetics in Medicine

Volume: 21, P: 62-70
Correction: A homozygous FANCM frameshift pathogenic variant causes male infertility

Hao Yin
Hui Ma
Qinghua Shi
Amendments and CorrectionsOpen Access29 Aug 2018
Genetics in Medicine

Volume: 21, P: 266

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A single mutation may contribute to accelerated evolution of SARS-CoV-2 toward Omicron

Vaginal microbiome and sexually-transmitted pathogens in Chinese reproductive-age women: a multicentre cross-sectional and longitudinal cohort study

SEPTIN2 suppresses an IFN-γ-independent, proinflammatory macrophage activation pathway

IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection

Association analysis identifies new risk loci for congenital heart disease in Chinese populations

Child-trafficking networks of illegal adoption in China

Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival

Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC

A homozygous FANCM frameshift pathogenic variant causes male infertility

Correction: A homozygous FANCM frameshift pathogenic variant causes male infertility

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