USP28 and 53BP1 proteins form a complex to stabilise the tumour suppressor p53, which is required to protect cells from mitotic stress and subsequent genome instability. Here, the authors discover that missense mutations in the C-terminal region of USP28 disrupt 53BP1 interaction and p53 stabilization.
- Hazrat Belal
- Esther Feng Ying Ng
- Franz Meitinger
