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Showing 1–2 of 2 results
Advanced filters: Author: Belinda Beqo Clear advanced filters

  • Parathyroid hormone (PTH) is an endogenous hormone and osteoporosis therapeutic that suppresses sclerostin activity. Here the authors develop SIK inhibitors as potential therapeutic tools and use them to show that PTH-cAMP signalling in osteocytes inhibits SIK2 from driving Hdac4/5 nuclear shuttling to suppress sclerostin.

    • Marc N. Wein
    • Yanke Liang
    • Henry M. Kronenberg
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-19