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Advanced filters: Author: Benedict-Tilman Berger Clear advanced filters

  • CDK11 associates with SF3B1 and phosphorylates threonine residues at the N terminus of SF3B1 during spliceosome activation, and the inhibition of CDK11 blocks the activation and leads to widespread intron retention and the accumulation of non-functional spliceosomes on pre-mRNAs and chromatin.

    • Milan Hluchý
    • Pavla Gajdušková
    • Dalibor Blazek
    Research
    Nature
    Volume: 609, P: 829-834