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Showing 1–12 of 12 results
Advanced filters: Author: Benedikt Westermann Clear advanced filters

  • Organelles called mitochondria have essential roles in the cell and must be inherited successfully as it divides. It turns out that three types of interaction with filaments of actin protein mix and partition mitochondria during cell division.

    • Till Klecker
    • Benedikt Westermann
    News & Views
    Nature
    Volume: 591, P: 535-537

  • Alternative lengthening of telomeres (ALT) is associated with a poor outcome in neuroblastoma. Here, the authors find that ALT is associated with mutated ATRX and/or reduced protein abundance, frequent telomeric repeat loci and heterochromatic telomeric chromatin.

    • Sabine A. Hartlieb
    • Lina Sieverling
    • Frank Westermann
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Analyses of genomes from 914 children, adolescents, and young adults provide a comprehensive resource of genomic alterations across a spectrum of common childhood cancers.

    • Susanne N. Gröbner
    • Barbara C. Worst
    • Stefan M. Pfister
    ResearchOpen Access
    Nature
    Volume: 555, P: 321-327

  • Organic acidurias are inherited disorders that can severely affect mitochondria. A study in Caenorhabditis elegans suggests that binding of a toxic metabolite to a factor crucial for mitochondrial structure may contribute to disease mechanisms.

    • Till Klecker
    • Benedikt Westermann
    News & Views
    Nature Cell Biology
    Volume: 24, P: 410-412

  • Two complementary proteomics approaches promise to move us closer to definition of the complete complement of proteins that make up a mitochondrion.

    • Benedikt Westermann
    • Walter Neupert
    News & Views
    Nature Biotechnology
    Volume: 21, P: 239-240

  • The continuous fusion and fission of mitochondria is important for their inheritance and function. The core components of the fusion and fission machineries, and the mechanisms that regulate these processes, have recently been elucidated and found to be integral for the maintenance of cellular quality control.

    • Benedikt Westermann
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 872-884

  • The Microarray Quality Control consortium pitted 36 teams against each other to evaluate methods for creating genomic classifiers, computational tools for interpreting gene expression profiles. The performance of the classifiers on blinded validation data—and metadata on the analytic methods—reveal the challenges facing the field.

    • Leming Shi
    • Gregory Campbell
    • Russell D Wolfinger
    Research
    Nature Biotechnology
    Volume: 28, P: 827-838

  • Schnabel et al. identify and characterize piperine synthase in developing black pepper fruits which catalyses the formation of piperine from piperoyl coenzyme A and piperidine. A member of BAHD-type acyltransferases, this enzyme can be useful for bio-production of a broad range of medicinally relevant piperamides.

    • Arianne Schnabel
    • Benedikt Athmer
    • Thomas Vogt
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-10