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Showing 1–4 of 4 results

Advanced filters: Author: Bengt-Frederik Belgardt Clear advanced filters

SIK2 regulates insulin secretion

Correct regulation of insulin secretion by the pancreas is crucial for organismal function and survival. The AMPK-related kinase SIK2 (salt-inducible kinase 2) is now shown to be stabilized in pancreatic β-cells following glucose stimulation, leading to improved systemic glucose homeostasis by regulating cellular calcium flux and insulin secretion.

Bengt-Frederik Belgardt
Markus Stoffel
News & Views28 Feb 2014
Nature Cell Biology

Volume: 16, P: 210-212
The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes

The miR-200 family of miRNAs is upregulated in diabetes and leads to the apoptosis of pancreatic beta cells, while its knockout prevents this pathology

Bengt-Frederik Belgardt
Kashan Ahmed
Markus Stoffel
Research18 May 2015
Nature Medicine

Volume: 21, P: 619-627
Semaphorin-3A regulates liver sinusoidal endothelial cell porosity and promotes hepatic steatosis

Eberhard et al. show that SEMA3A regulates liver sinusoidal endothelial cell fenestrations by signaling through NRP1 and LIMK1, revealing a pathway that connects hyperlipidemia to the development of steatotic liver disease.

Daniel Eberhard
Sydney Balkenhol
Eckhard Lammert
ResearchOpen Access14 Jun 2024
Nature Cardiovascular Research

Volume: 3, P: 734-753
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis

Griess et al. determine the lipid signatures of pancreatic islets in type 2 diabetes models. They define a lipid environment linking the endoplasmic reticulum–Golgi transport protein Tmed2 to the proinsulin processing enzyme Pcsk1 to ensure insulin production.

Kerstin Griess
Michael Rieck
Bengt-Frederik Belgardt
ResearchOpen Access21 Dec 2022
Nature Cell Biology

Volume: 25, P: 20-29