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Showing 1–18 of 18 results
Advanced filters: Author: Benjamin A. Youngblood Clear advanced filters

  • Poor persistence limits the efficacy of cellular immunotherapies. Three studies now show how the quiescence factor BACH2 can be exploited to improve the therapeutic potential of T cell immunotherapy.

    • Rajshekhar Alli
    • Ben Youngblood
    News & Views
    Nature Immunology
    P: 1-2

  • In this Viewpoint article, Nature Reviews Immunology invites 18 experts to discuss the nature of T cell exhaustion. How should T cell exhaustion be defined and what are the developmental relationships between exhausted T cell subsets? The contributors share their thoughts on key recent developments in the field.

    • Christian U. Blank
    • W. Nicholas Haining
    • Dietmar Zehn
    Reviews
    Nature Reviews Immunology
    Volume: 19, P: 665-674

  • Starting on 19 September 2022, the very first ImmunOctoberfest conference took place in Raitenhaslach, Germany, bringing together scientists from all over the world to discuss ‘bridging innovation and translation in T cell immunotherapy’.

    • Anna M. Schulz
    • Caitlin C. Zebley
    • Dietmar Zehn
    News & Views
    Nature Immunology
    Volume: 24, P: 213-215

  • Autoreactive T cells are subject to continuous antigenic stimulation yet sustain their autoreactive functionality. Youngblood and colleagues examine type 1 diabetes systems to show that a pool of autoreactive CD8+ T cells exhibits a stem cell–like signature that facilitates their durable activity.

    • Hossam A. Abdelsamed
    • Caitlin C. Zebley
    • Ben Youngblood
    Research
    Nature Immunology
    Volume: 21, P: 578-587

  • Adoptive transfer of regulatory T (Treg) cells holds promise for the treatment of inflammatory diseases, but maintaining a therapeutic capacity is challenging. Here, the authors show that engineering Tregs to express an IL-2 partial agonist enhances Treg persistence and suppression of inflammation in mouse models, representing a potential optimization for Treg therapy.

    • Janie Robert
    • Manon Feuillolay
    • David Klatzmann
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Chronic antigen exposure promotes terminal exhaustion of T cells. Here the authors show a role for TCR stimulation in preserving progenitor exhausted T cells and highlight their TCR-dependent self-renewal during antitumor responses.

    • Xin Lan
    • Tian Mi
    • Ben Youngblood
    Research
    Nature Immunology
    Volume: 25, P: 1046-1058

  • Through iterative cycles of viral challenge and rechallenge over ten years, mouse T cells are demonstrated to have essentially infinite potential for population expansion and longevity without malignant transformation or loss of functional competence.

    • Andrew G. Soerens
    • Marco Künzli
    • David Masopust
    Research
    Nature
    Volume: 614, P: 762-766

  • Transcriptional and epigenetic mechanisms governing T cell exhaustion substantially impact immunotherapy effectiveness. In this Review, Kang et al. outline epigenetic regulatory programmes that influence T cell differentiation fates, proposing strategies to enhance clinical outcomes and immunotherapy durability in cancer through improved understanding of T cell biology.

    • Tae Gun Kang
    • Jordan T. Johnson
    • Ben Youngblood
    Reviews
    Nature Reviews Cancer
    Volume: 26, P: 46-61

  • Durable agonism of NPR1 achieved with a novel investigational monoclonal antibody could mirror the positive hemodynamic changes in blood pressure and heart failure identified in humans with lifelong exposure to NPR1 coding variants.

    • Michael E. Dunn
    • Aaron Kithcart
    • Lori Morton
    ResearchOpen Access
    Nature
    Volume: 633, P: 654-661

  • Observations from the JWST show the presence of a spectral absorption feature at 4.05 μm arising from SO2 in the atmosphere of the gas giant exoplanet WASP-39b, which is produced by photochemical processes and verified by numerical models.

    • Shang-Min Tsai
    • Elspeth K. H. Lee
    • Sergei N. Yurchenko
    ResearchOpen Access
    Nature
    Volume: 617, P: 483-487

  • Tissue-resident memory (TRM) cells are generally stably maintained in discrete tissues or organs. Masopust and colleagues show that TRM cells can reenter the circulation, and exhibit considerable plasticity, although they retain a proclivity to reestablish themselves in their tissue of origin.

    • Raissa Fonseca
    • Lalit K. Beura
    • David Masopust
    Research
    Nature Immunology
    Volume: 21, P: 412-421

  • New reports provide further insight into the role of the transcription factor BATF in pivoting the differentiation of CD8+ T cells away from T cell exhaustion and facilitating the transition of these cells into potent effectors.

    • Shannon K. Boi
    • Xin Lan
    • Ben Youngblood
    News & Views
    Nature Immunology
    Volume: 22, P: 936-938

  • Using an iterative boost and transplantation model to generate multilifetime T cells, Mi et al. show that cellular epigenetic age can be uncoupled from organism age. While naive T cells appear epigenetically young, memory T cells and T-ALL leukemia can exhibit epigenetic ages exceeding the organismal lifespan.

    • Tian Mi
    • Andrew G. Soerens
    • Ben Youngblood
    ResearchOpen Access
    Nature Aging
    Volume: 4, P: 1053-1063

  • DNA methylation profiling of virus-specific T cells during acute viral infection in mice provides evidence that a fate-permissive subset of effector CD8 T cells dedifferentiates into long-lived memory T cells.

    • Ben Youngblood
    • J. Scott Hale
    • Rafi Ahmed
    Research
    Nature
    Volume: 552, P: 404-409