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Interaction of the mitochondrial calcium/proton exchanger TMBIM5 with MICU1

Genetic and biochemical evidence reveals a functional interaction between mitochondrial proteins TMBIM5 and MICU1.

Li Zhang
Benjamin Gottschalk
Axel Methner
ResearchOpen Access19 Sept 2025
Communications Biology

Volume: 8, P: 1-13
Author Correction: Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial

Ken Mautner
Michael Gottschalk
Hicham Drissi
Amendments and CorrectionsOpen Access22 Dec 2023
Nature Medicine

Volume: 30, P: 905
Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial

The multicenter phase 3 trial of stem cell therapy for osteoarthritis (MILES) for knee pain revealed that cell therapies showed no significant difference in knee pain outcomes, compared to corticosteroid injections, 1 year following treatment.

Ken Mautner
Michael Gottschalk
Hicham Drissi
ResearchOpen Access02 Nov 2023
Nature Medicine

Volume: 29, P: 3120-3126
Tapping the keg of discovery to advance T cell therapy

Starting on 19 September 2022, the very first ImmunOctoberfest conference took place in Raitenhaslach, Germany, bringing together scientists from all over the world to discuss ‘bridging innovation and translation in T cell immunotherapy’.

Anna M. Schulz
Caitlin C. Zebley
Dietmar Zehn
News & Views11 Jan 2023
Nature Immunology

Volume: 24, P: 213-215
MICU1 controls cristae junction and spatially anchors mitochondrial Ca²⁺ uniporter complex

Proper mitochondrial structure is critical for normal function. Here, the authors show with SIM that the mitochondrial Ca²⁺ uniporter complex and localization of component MICU1 is critical to maintaining cristae junction stability and overall mitochondrial membrane structure.

Benjamin Gottschalk
Christiane Klec
Wolfgang F. Graier
ResearchOpen Access19 Aug 2019
Nature Communications

Volume: 10, P: 1-17
PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca²⁺ uptake in immortalized cells

MICU1 is a regulatory subunit of mitochondrial Ca²⁺ channels that shields mitochondria from Ca²⁺ overload. Here the authors show that MICU1 methylation by PRMT1 reduces Ca²⁺ sensitivity, which is normalized by UCP2/3, re-establishing mitochondrial Ca²⁺uptake activity.

Corina T. Madreiter-Sokolowski
Christiane Klec
Wolfgang F. Graier
ResearchOpen Access19 Sept 2016
Nature Communications

Volume: 7, P: 1-13
Development of novel FP-based probes for live-cell imaging of nitric oxide dynamics

Nitric oxide is a volatile free radical second messenger with a large number of biological effects. Here Eroglu et al. develop genetically encoded fluorescent biosensors for nitric oxide and use them to visualise subcellular nitric oxide dynamics in single cells.

Emrah Eroglu
Benjamin Gottschalk
Roland Malli
ResearchOpen Access04 Feb 2016
Nature Communications

Volume: 7, P: 1-11
Structural surfaceomics reveals an AML-specific conformation of integrin β₂ as a CAR T cellular therapy target

Wiita and colleagues use cross-linking mass spectrometry and glycoprotein surface capture to identify an activated conformation of integrin β₂ present on AML cells and develop CAR T cells that target this conformation antigen in preclinical models.

Kamal Mandal
Gianina Wicaksono
Arun P. Wiita
ResearchOpen Access30 Oct 2023
Nature Cancer

Volume: 4, P: 1592-1609
Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo

K⁺ plays an important role in physiology and disease, but the lack of high specificity K⁺ sensors limits our understanding of its spatiotemporal dynamics. Here the authors develop genetically-encoded FRET-based probes able to quantify K⁺ concentration in body fluids, cells and specific organelles.

Helmut Bischof
Markus Rehberg
Roland Malli
ResearchOpen Access10 Nov 2017
Nature Communications

Volume: 8, P: 1-12
The Role of PGE₂ in Alveolar Epithelial and Lung Microvascular Endothelial Crosstalk

Thomas Bärnthaler
Jovana Maric
Akos Heinemann
ResearchOpen Access11 Aug 2017
Scientific Reports

Volume: 7, P: 1-17
Implications of mitochondrial membrane potential gradients on signaling and ATP production analyzed by correlative multi-parameter microscopy

Benjamin Gottschalk
Zhanat Koshenov
Wolfgang F. Graier
ResearchOpen Access26 Jun 2024
Scientific Reports

Volume: 14, P: 1-12
Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

Tissue mimics are of great interest in understanding diseases. Here, organoids were developed that resemble polycystic kidney disease cysts and it was demonstrated how material environment and adhesion can affect cystogenesis and disease progression.

Nelly M. Cruz
Xuewen Song
Benjamin S. Freedman
Research02 Oct 2017
Nature Materials

Volume: 16, P: 1112-1119
Citrin mediated metabolic rewiring in response to altered basal subcellular Ca²⁺ homeostasis

Koshenov et al. investigate the regulation of basal mitochondrial bioenergetics and find that Ca²⁺ fluxes from ER-mitochondria contact sites control basal mitochondrial metabolism and energetics. The authors identify citrin as a primary regulator of this process and show that manipulation of Ca²⁺ dynamics can reprogram cellular and mitochondrial metabolism.

Zhanat Koshenov
Furkan E. Oflaz
Wolfgang F. Graier
ResearchOpen Access20 Jan 2022
Communications Biology

Volume: 5, P: 1-15
MICU1 controls spatial membrane potential gradients and guides Ca²⁺ fluxes within mitochondrial substructures

Within mitochondrial substructures, MICU1 is shown to mediate Ca²⁺ control over spatial membrane potential gradients (SMPGs), with alterations in SMPGs following Ca²⁺ binding to MICU1 resulting in spatial cristae depolarization.

Benjamin Gottschalk
Zhanat Koshenov
Wolfgang F. Graier
ResearchOpen Access01 Jul 2022
Communications Biology

Volume: 5, P: 1-13
Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca²⁺

Markus Waldeck-Weiermair
Roland Malli
Wolfgang F. Graier
ResearchOpen Access22 Oct 2015
Scientific Reports

Volume: 5, P: 1-10
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15

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