Nature Search

Interface strain in vertically stacked two-dimensional heterostructured carbon-MoS₂ nanosheets controls electrochemical reactivity

Two-dimensional materials are promising for electrochemical energy storage, conversion, catalysis, and sensing. Here the authors leverage strain engineering using a two-dimensional stacked carbon-MoS₂ material to control chemical storage pathways in MoS₂upon lithium metal insertion.

Landon Oakes
Rachel Carter
Cary L. Pint
ResearchOpen Access03 Jun 2016
Nature Communications

Volume: 7, P: 1-7
Role of biogenic silica in the removal of iron from the Antarctic seas

Iron plays a key role in controlling biological production in the Southern Ocean, yet mechanisms regulating iron availability are not completely understood. Here, Ingall et al.show that structural incorporation of reduced, organic iron into biogenic silica represents a new and substantial removal pathway.

Ellery D. Ingall
Julia M. Diaz
Jay A. Brandes
Research10 Jun 2013
Nature Communications

Volume: 4, P: 1-6
Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing

Zinc finger nucleases have an established role in genome editing. Here, the authors report a strategy for identifying zinc finger nucleases that discriminate between desired targets and provide genome-wide specificity.

Benjamin L. Oakes
Danny F. Xia
Marcus B. Noyes
ResearchOpen Access07 Jan 2016
Nature Communications

Volume: 7, P: 1-13
Pteropods counter mechanical damage and dissolution through extensive shell repair

Sea butterflies, or pteropods, are often presented as being at threat from ocean acidification on account of their fragile shells being susceptible to dissolution. Here the authors show that pteropods are able to perform extensive repair to damaged shells, suggesting they may not be as vulnerable as previously thought.

Victoria L. Peck
Rosie L. Oakes
Geraint A. Tarling
ResearchOpen Access17 Jan 2018
Nature Communications

Volume: 9, P: 1-7
CasX enzymes comprise a distinct family of RNA-guided genome editors

CRISPR–CasX represents a distinct RNA-guided platform that is functionally separate from Cas9 and Cas12a and is active for bacterial and human genome modification.

Jun-Jie Liu
Natalia Orlova
Jennifer A. Doudna
Research04 Feb 2019
Nature

Volume: 566, P: 218-223
Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia

Analysis of exomes and transcriptomes from 100 African American patients with acute myeloid leukemia identifies ancestry-related variation in mutation profiles and survival. Refined risk classification suggests clinical relevance of these ancestry-associated differences.

Andrew Stiff
Maarten Fornerod
Ann-Kathrin Eisfeld
ResearchOpen Access04 Oct 2024
Nature Genetics

Volume: 56, P: 2434-2446
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs

Control of CRISPR-Cas9 activity allows for fine-tuning of editing and gene expression. Here the authors use gRNAs modified with RNA aptamers to enable small molecule control in bacterial systems.

Kale Kundert
James E. Lucas
Tanja Kortemme
ResearchOpen Access09 May 2019
Nature Communications

Volume: 10, P: 1-11
Author Correction: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

Tony P. Huang
Kevin T. Zhao
David R. Liu
Amendments and Corrections10 Jun 2019
Nature Biotechnology

Volume: 37, P: 820
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

Wider editing windows and different PAM requirements enable a broad set of genomic positions to be targeted with A and C base editors.

Tony P. Huang
Kevin T. Zhao
David R. Liu
Research20 May 2019
Nature Biotechnology

Volume: 37, P: 626-631
Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors

Jun-Jie Liu
Natalia Orlova
Jennifer A. Doudna
Amendments and Corrections03 Apr 2019
Nature

Volume: 568, P: E8-E10
β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

Phagocytosis is regulated by the mechanical properties of both the phagocyte and its cargo. Here, the authors show that macrophages employ β2 integrins to sense the rigidity of phagocytic cargo and then mount the appropriate form of engulfment.

Alexander H. Settle
Benjamin Y. Winer
Morgan Huse
ResearchOpen Access18 Sept 2024
Nature Communications

Volume: 15, P: 1-20
Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules

Proteins evolve through the modular rearrangement of domains. Here the authors introduce MISER, a minimization by iterative size-exclusion and recombination method to make all possible deletions of a protein, uncovering functions for Cas9 domains involved in DNA binding.

Arik Shams
Sean A. Higgins
David F. Savage
ResearchOpen Access27 Sept 2021
Nature Communications

Volume: 12, P: 1-11
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

A survey of T cell repertoire evolution in the tumors, healthy tissue and blood of patients with early-stage untreated lung cancer offers an opportunity to monitor and identify neoantigen-specific T cells for personalized immunotherapy.

Kroopa Joshi
Marc Robert de Massy
Benny Chain
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1549-1559
Cancer-associated fibroblasts are associated with neo-adjuvant treatment response in oesophageal adenocarcinoma

Robert C. Walker
Stella P. Breininger
Timothy J. Underwood
ResearchOpen Access10 Jul 2025
British Journal of Cancer

Volume: 133, P: 633-647
Publisher Correction: Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

Kroopa Joshi
Marc Robert de Massy
Benny Chain
Amendments and Corrections03 Jun 2020
Nature Medicine

Volume: 26, P: 1148
Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch

A small-molecule-inducible Cas9 variant with very low background activity is identified by screening for sites that can tolerate domain insertions.

Benjamin L Oakes
Dana C Nadler
David F Savage
Research02 May 2016
Nature Biotechnology

Volume: 34, P: 646-651
Programmable RNA recognition and cleavage by CRISPR/Cas9

In the presence of a short DNA oligonucleotide containing a protospacer adjacent motif, a guide-RNA-programmed Cas9 is able to specifically bind and/or cleave single-stranded RNA—this system can be used to isolate specific endogenous RNA transcripts from a cell lysate without any tag or modification.

Mitchell R. O’Connell
Benjamin L. Oakes
Jennifer A. Doudna
Research28 Sept 2014
Nature

Volume: 516, P: 263-266
The T cell differentiation landscape is shaped by tumour mutations in lung cancer

Ghorani et al. use a multiomics approach to characterize the effect of tumour mutational burden on the differentiation of CD4 and CD8 T cell subpopulations in non-small cell lung cancer.

Ehsan Ghorani
James L. Reading
Sergio A. Quezada
Research22 May 2020
Nature Cancer

Volume: 1, P: 546-561
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy

A new engineered version of SpCas9, called HypaCas9, displays enhanced accuracy of editing without significant loss of efficiency at the desired target.

Janice S. Chen
Yavuz S. Dagdas
Jennifer A. Doudna
Research20 Sept 2017
Nature

Volume: 550, P: 407-410

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