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Showing 1–12 of 12 results
Advanced filters: Author: Benjamin Sussman Clear advanced filters

  • Using entangled photons, researchers develop a non-interferometric, scanning-free quantum phase microscope enabling high-resolution, quantitative phase imaging of transparent samples at ultralow light levels and resilient to background noise.

    • Yingwen Zhang
    • Paul-Antoine Moreau
    • Benjamin Sussman
    ResearchOpen Access
    Nature Communications
    P: 1-9

  • Controlling the spectral properties of single photons is important for emerging optical quantum technologies, but doing so in a frequency-multiplexed framework is challenging. Here, the authors demonstrate quantum frequency conversion with a Raman quantum memory in room-temperature diamond.

    • Kent A. G. Fisher
    • Duncan G. England
    • Benjamin J. Sussman
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-6

  • A proteolytically derived fragment of the epigenetic regulator HDAC4 protects the heart through transcriptional repression of the hexosamine biosynthetic pathway, thereby inhibiting protein O-GlcNAcylation and maintaining normal calcium handling and contractility of cardiomyocytes.

    • Lorenz H Lehmann
    • Zegeye H Jebessa
    • Johannes Backs
    Research
    Nature Medicine
    Volume: 24, P: 62-72

  • Evolution of osmoregulation allowed photosynthetic organisms to transform the whole biosphere. Leveraging high-throughput techniques in the freshwater alga Chlamydomonas reinhardtii, the authors uncover evolutionary conservation and divergence of osmoregulatory pathways within the green lineage.

    • Josep Vilarrasa-Blasi
    • Tamara Vellosillo
    • José R. Dinneny
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • This Review describes advances in artificial and bioartificial liver support systems and current developments. The evolving field of hepatocyte transplantation as a less invasive alternative to whole-organ transplantation is also reviewed, and a detailed overview of cutting-edge hepatic tissue engineering is included. Challenges and opportunities of the different approaches are analysed with respect to clinical relevance, as well as basic science concerns.

    • Benjamin Struecker
    • Nathanael Raschzok
    • Igor M. Sauer
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 11, P: 166-176

  • Exosomes originating from lung-, liver- and brain-tropic tumour cells are preferentially incorporated by specific resident cells of the target organs, thus preparing the site for metastasis; the expression of distinct combinations of exosomal integrin proteins determines the exosomal targeting to each of the three organs, and blocking these integrins reduces organotropic exosome uptake by the target organs, thereby reducing the likelihood of organotropic metastasis.

    • Ayuko Hoshino
    • Bruno Costa-Silva
    • David Lyden
    Research
    Nature
    Volume: 527, P: 329-335

  • The Cancer Genome Atlas Network describe their multifaceted analyses of primary breast cancers, shedding light on breast cancer heterogeneity; although only three genes (TP53, PIK3CA and GATA3) are mutated at a frequency greater than 10% across all breast cancers, numerous subtype-associated and novel mutations were identified.

    • Daniel C. Koboldt
    • Robert S. Fulton
    • Jacqueline D. Palchik
    ResearchOpen Access
    Nature
    Volume: 490, P: 61-70

  • Exosomes can transfer proteins and nucleic acids from one cell to another, altering the phenotype of the recipient cell. In the case of cancer, tumor-derived exosomes have been shown to promote tumor cell proliferation. Now, in a mouse model of melanoma, Peinado et al. report that exosomes derived from highly metastatic tumor cells can influence bone marrow cells, resulting in increased recruitment of provasculogenic bone marrow progenitors to sites of metastasis, increased primary tumor growth and metastatic spread.

    • Héctor Peinado
    • Maša Alečković
    • David Lyden
    Research
    Nature Medicine
    Volume: 18, P: 883-891

  • Comprehensive analyses of 178 lung squamous cell carcinomas by The Cancer Genome Atlas project show that the tumour type is characterized by complex genomic alterations, with statistically recurrent mutations in 11 genes, including TP53 in nearly all samples; a potential therapeutic target is identified in most of the samples studied.

    • Peter S. Hammerman
    • Michael S. Lawrence
    • Matthew Meyerson
    ResearchOpen Access
    Nature
    Volume: 489, P: 519-525

  • Polyphenols are widely studied as potential drugs for Alzheimer’s disease, but their development is limited by poor bioavailability. Here polyphenolic analogues of the Alzheimer's disease drug rivastigmine are shown to inhibit both cholinesterase and amyloid beta fibrillation in vitro and in vivo in a C. elegans model, providing a potentially general route for the development of polyphenol-based drugs.

    • Satish N. Dighe
    • Eugenio De la Mora
    • Benjamin P. Ross
    ResearchOpen Access
    Communications Chemistry
    Volume: 2, P: 1-14