Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–7 of 7 results
Advanced filters: Author: Benjamin T. Goult Clear advanced filters

  • The mechanosensitive proteins talin and vinculin mediate the linkage between integrin-bound extracellular matrix and the actin cytoskeleton. Here the authors dissect distinct roles for two actin-binding sites within talin on adhesion complex assembly and maturation, which are regulated by vinculin binding to talin.

    • Paul Atherton
    • Ben Stutchbury
    • Christoph Ballestrem
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Talin is a mechanosensing cytoplasmic adaptor that links integrin cell adhesion receptors to the actin cytoskeleton. Here the authors measure the force-dependent folding and refolding kinetics of all talin rod domains to propose that talin can function as a force buffer under physiologically relevant conditions.

    • Mingxi Yao
    • Benjamin T. Goult
    • Jie Yan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • An engineered version of the mechanosensitive protein talin was used as a monomer in combination with a synthetic chemical crosslinker to form a hydrogel. This shock-absorbing material is shown to capture and preserve projectiles fired at 1.5 km s−1.

    • Jack A. Doolan
    • Luke S. Alesbrook
    • Benjamin T. Goult
    ResearchOpen Access
    Nature Nanotechnology
    Volume: 18, P: 1060-1066

  • Assembly of transcriptional repression complexes involves the recruitment of different proteins to SMRT or its homolog NCoR. Now structural and functional work reveal the tetrameric organization of the oligomerization domain of TBL1 and map its interactions with SMRT and GPS2. The authors propose a model for the architecture and assembly of the corepressor complex.

    • Jasmeen Oberoi
    • Louise Fairall
    • John W R Schwabe
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 177-184