Nature Search

Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities

Benoit Bilanges
Annie Varrault
Laurent Journot
Research10 Apr 2001
Oncogene

Volume: 20, P: 1246-1253
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Vps34 is a lipid kinase conserved from yeast to humans and involved in in intracellular vesicular trafficking and autophagy. Here Bilanges et al. show that inhibition of this kinase in mice improves glucose tolerance and diet-induced steatosis by modulating mitochondrial respiration and metabolism.

Benoit Bilanges
Samira Alliouachene
Bart Vanhaesebroeck
ResearchOpen Access27 Nov 2017
Nature Communications

Volume: 8, P: 1-14
Killing two kinase families with one stone

Multitargeted protein kinase inhibitors have shown great promise in cancer therapy, but the selectivity profiles of these compounds have largely relied on serendipity or 'off-target' activities rather than rational drug design. Purposefully designed compounds with activity against multiple target kinases bring us a step closer to personalized medicine.

Benoit Bilanges
Neil Torbett
Bart Vanhaesebroeck
News & Views01 Nov 2008
Nature Chemical Biology

Volume: 4, P: 648-649
A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease

Primary cilia are cell organelles disrupted in developmental diseases and cancer. Here, the authors identify cilia regulators that generate a specific cilia membrane lipid, which may help to better understand diseases caused by mutations in PI3-kinase subunits.

Sarah E. Conduit
Wayne Pearce
Bart Vanhaesebroeck
ResearchOpen Access21 Aug 2024
Nature Communications

Volume: 15, P: 1-21
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

A new specific, small-molecule activator of the PI3Kα isoform (UCL-TRO-1938) identified through high-throughput screening can transiently activate PI3K signalling and biological responses in cells and tissues, with potential therapeutic applications in tissue protection and regeneration.

Grace Q. Gong
Benoit Bilanges
Bart Vanhaesebroeck
Research24 May 2023
Nature

Volume: 618, P: 159-168
Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors

Benoit Bilanges
Annie Varrault
Laurent Journot
Research14 Jul 1999
Oncogene

Volume: 18, P: 3979-3988
Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation

Heteroplasmic mtDNA mutations cause disease in humans. Here, Chung et al find the PI3K-Akt-mTORC1 pathway constitutively activated in cells with the heteroplasmic m.3243 A > G mutation, and inhibition of the pathway cell autonomously reduces mutant mtDNA load and rescues mitochondrial bioenergetics.

Chih-Yao Chung
Kritarth Singh
Michael R. Duchen
ResearchOpen Access04 Nov 2021
Nature Communications

Volume: 12, P: 1-16
The emerging mechanisms of isoform-specific PI3K signalling

Phosphoinositide 3-kinases (PI3Ks), of which there are eight isoforms, function early in intracellular signal transduction pathways and affect many biological functions. Understanding how these isoforms are differentially regulated and how they control signalling might provide new insight into their roles in disease.

Bart Vanhaesebroeck
Julie Guillermet-Guibert
Benoit Bilanges
Reviews09 Apr 2010
Nature Reviews Molecular Cell Biology

Volume: 11, P: 329-341
PI3K isoforms in cell signalling and vesicle trafficking

Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that generate 3-phosphoinositides, which govern cellular signal transduction and membrane trafficking. The PI3K family comprises three classes of enzymes, which include several isoforms and complexes; the myriad of cellular functions and means of regulation of these enzymes are now coming into focus.

Benoit Bilanges
York Posor
Bart Vanhaesebroeck
Reviews20 May 2019
Nature Reviews Molecular Cell Biology

Volume: 20, P: 515-534
Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency

Giuseppina Grieco
Virginie Janssens
Pierre J. Courtoy
ResearchOpen Access20 Sept 2018
Scientific Reports

Volume: 8, P: 1-16

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