In this study, the authors show that age-related aberrant synaptic remodeling in the retinal outer plexiform layer is mediated by LBK1-AMPK signaling. They also show that treatments which elevate AMPK signaling, including caloric restriction or administration of metformin, can ameliorate these deficits.
- Melanie A Samuel
- P Emanuela Voinescu
- Joshua R Sanes
