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Showing 1–2 of 2 results
Advanced filters: Author: Benoite Champon Clear advanced filters

  • A coding variant of the PAX4 transcription factor (p.Arg192His) is uniquely associated with Type 2 Diabetes in East Asian populations. Here, the authors show that two different coding gene variants of PAX4, p.Arg192His and the newly identified p.Tyr186X, can influence pancreatic beta cell development, identity, and function.

    • Hwee Hui Lau
    • Nicole A. J. Krentz
    • Adrian Kee Keong Teo
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • The rare loss-of-function allele p.Arg138* in SLC30A8 (encoding ZnT8) mediates protection against type 2 diabetes (T2D) through promoting better insulin secretion and enhanced glucose responsiveness, suggesting ZnT8 as a target for T2D treatment.

    • Om Prakash Dwivedi
    • Mikko Lehtovirta
    • Leif Groop
    Research
    Nature Genetics
    Volume: 51, P: 1596-1606