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Advanced filters: Author: Benu Brata Das Clear advanced filters

  • Here, the authors reveal that PRMT5 localizes to mitochondria to preserve mtDNA homeostasis. Its loss disrupts nucleoids, mtDNA copy number, dynamics, and respiration. PRMT5 methylates TFAM at R82, stabilizing it against LonP1 degradation and enabling mtDNA protection.

    • Sangheeta Bhattacharjee
    • Sayan Das
    • Benu Brata Das
    ResearchOpen Access
    Nature Communications
    P: 1-20