The protein thioredoxin regulates the activity of many signalling molecules. Here, Hwang et al.report structural and biochemical evidence that the interaction between thioredoxin and its inhibitor thioredoxin-interacting protein is regulated by a redox-dependent disulphide bond-switching mechanism.
- Jungwon Hwang
- Hyun-Woo Suh
- Myung Hee Kim
