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Overcoming EGFR^G724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors

Acquired resistance to targeted drugs remains a major clinical challenge in lung adenocarcinoma patients. Here, the authors show how the acquired EGFR^G724S mutation induces resistance to third-generation EGFR inhibitors and why the mutant kinase remains susceptible to second-generation inhibitors.

Jana Fassunke
Fabienne Müller
Martin L. Sos

ResearchOpen Access07 Nov 2018

Nature Communications

Volume: 9, P: 1-13

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Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

Overcoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors

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Overcoming EGFR^G724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors