This study identifies a shift from canonical to non-canonical Wnt signalling in ageing haematopoietic stem cells (HSCs); elevated expression of Wnt5a in aged HSCs has a causal role in stem-cell ageing, and this is mediated by the small Rho GTPase Cdc42.
- Maria Carolina Florian
- Kalpana J. Nattamai
- Hartmut Geiger