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Showing 1–11 of 11 results
Advanced filters: Author: Beverly A Heinz Clear advanced filters

  • Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

    • Xia Jiang
    • Hilary K. Finucane
    • Sara Lindström
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-23

  • Desmoplastic Small Round Cell Tumor (DSRCT) is an aggressive malignancy characterized by EWS-WT1 fusion oncoproteins with limited mechanistic understanding. Here, the authors identify EWS-WT1-dependent gene regulation networks and target genes, as well as the activities of two EWS-WT1 isoforms with distinct DNA binding profiles, both of which are indispensable for DSRCT formation.

    • Gaylor Boulay
    • Liliane C. Broye
    • Nicolò Riggi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • This paper reports the genome sequence of domesticated tomato, a major crop plant, and a draft sequence for its closest wild relative; comparative genomics reveal very little divergence between the two genomes but some important differences with the potato genome, another important food crop in the genus Solanum.

    • Shusei Sato
    • Satoshi Tabata
    • René M. Klein Lankhorst
    ResearchOpen Access
    Nature
    Volume: 485, P: 635-641

  • In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cognitive function and to Parkinson's disease, and enriched near genes involved in growth pathways, including PI3K-AKT signaling.

    • Hieab H H Adams
    • Derrek P Hibar
    • Paul M Thompson
    Research
    Nature Neuroscience
    Volume: 19, P: 1569-1582

  • The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.

    • Derrek P. Hibar
    • Hieab H. H. Adams
    • M. Arfan Ikram
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

    • Gary A Churchill
    • David C Airey
    • Fei Zou
    Comments & Opinion
    Nature Genetics
    Volume: 36, P: 1133-1137