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Targeting calcineurin induces cardiomyocyte proliferation in adult mice

Lam et al. show that conditional deletion of calcineurin B1 in cardiomyocytes and its inhibition using the US Food and Drug Administration-approved drug, FK506, promotes cardiomyocyte cell-cycle re-entry and increases cardiomyocyte numbers in adult mice

Nicholas T. Lam
Ngoc Uyen Nhi Nguyen
Hesham A. Sadek
Research13 Jul 2022
Nature Cardiovascular Research

Volume: 1, P: 679-688
FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth

Disease stress-induced cardiac hypertrophy is a major mechanism of pathological cardiac remodeling. Here, the authors unveil a previously unrecognized role of a FoxO1–Dio2 signaling axis in maladaptive, afterload-induced cardiac hypertrophy and intracellular thyroid hormone homeostasis.

Anwarul Ferdous
Zhao V. Wang
Joseph A. Hill
ResearchOpen Access21 May 2020
Nature Communications

Volume: 11, P: 1-13
A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes

Hoxb13 acts as a cofactor of Meis1 in regulating cardiomyocyte maturation and cell cycle, and knockout of both proteins enables regeneration of postnatal cardiac tissue in a mouse model of heart injury.

Ngoc Uyen Nhi Nguyen
Diana C. Canseco
Hesham A. Sadek
Research22 Apr 2020
Nature

Volume: 582, P: 271-276
Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress

Norbert Frey
Tomasa Barrientos
Eric N Olson
Research14 Nov 2004
Nature Medicine

Volume: 10, P: 1336-1343
Author Correction: Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER–mitochondria communication during the early phase of ER stress

Roberto Bravo-Sagua
Valentina Parra
Sergio Lavandero
Amendments and Corrections11 Feb 2019
Cell Death & Differentiation

Volume: 26, P: 2494
Endoplasmic reticulum−mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells

Camila Lopez-Crisosto
Alexis Díaz-Vegas
Sergio Lavandero
ResearchOpen Access28 Jun 2021
Cell Death & Disease

Volume: 12, P: 1-12
Angiotensin-(1–9) prevents cardiomyocyte hypertrophy by controlling mitochondrial dynamics via miR-129-3p/PKIA pathway

Cristian Sotomayor-Flores
Pablo Rivera-Mejías
Sergio Lavandero
Research09 Mar 2020
Cell Death & Differentiation

Volume: 27, P: 2586-2604
Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER–mitochondria communication during the early phase of ER stress

Roberto Bravo-Sagua
Valentina Parra
Sergio Lavandero
ResearchOpen Access12 Sept 2018
Cell Death & Differentiation

Volume: 26, P: 1195-1212
mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling

Roberto Bravo-Sagua
Camila López-Crisosto
Sergio Lavandero
ResearchOpen Access03 Nov 2016
Scientific Reports

Volume: 6, P: 1-12
The integrated stress response in ischemic diseases

Guangyu Zhang
Xiaoding Wang
Zhao V. Wang
Reviews06 Nov 2021
Cell Death & Differentiation

Volume: 29, P: 750-757

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